Evidence map›Paper›PMID 24914278›Full record

ArticlePharmacognosy magazine2014

Effect of Aronia melanocarpa fruit juice on amiodarone-induced pneumotoxicity in rats.

Stefka Valcheva-Kuzmanova, Galya Stavreva, Violeta Dancheva, Ljudmil Terziev, Milena Atanasova, Angelina Stoyanova, Anelia Dimitrova, Veneta Shopova

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacognosy magazine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Antioxidants (Basel, Switzerland) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stefka Valcheva-KuzmanovaDepartment of Preclinical and Clinical Pharmacology and Toxicology, Medical University, Varna, Bulgaria.
Galya StavrevaDepartment of Experimental and Clinical Pharmacology, Medical University, Pleven, Bulgaria.
Violeta DanchevaDepartment of Disaster Medicine, Medical University, Pleven, Bulgaria.
Ljudmil TerzievDepartment of Clinical Laboratory, Clinical Immunologyand Allergology, Clinic of Allergology, University Hospital, Pleven, Bulgaria.
Milena AtanasovaDepartment of Biology, Medical University, Pleven, Bulgaria.
Angelina StoyanovaDepartment of Chemistry, Medical University, Pleven, Bulgaria.
Anelia DimitrovaDepartment of Physiology and Pathophysiology, Medical University, Pleven, Bulgaria.
Veneta ShopovaDepartment of Disaster Medicine, Medical University, Pleven, Bulgaria.
Medical University Pleven · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fruits of Aronia melanocarpa (Michx.) Elliot is extremely rich in biologically active polyphenols.

objectiveWe studied the protective effect of A. melanocarpa fruit juice (AMFJ) in a model of amiodarone (AD)-induced pneumotoxicity in rats. MATERIALS AND

methodsAD was instilled intratracheally on days 0 and 2 (6.25 mg/kg). AMFJ (5 mL/kg and 10 mL/kg) was given orally from day 1 to days 2, 4, 9, and 10 to rats, which were sacrificed respectively on days 3, 5, 10, and 28 when biochemical, cytological, and immunological assays were performed.

resultsAMFJ antagonized AD-induced increase of the lung weight coefficient. In bronchoalveolar lavage fluid, AD increased significantly the protein content, total cell count, polymorphonuclear cells, lymphocytes and the activity of lactate dehydrogenase, acid phosphatase and alkaline phosphatase on days 3 and 5. In AMFJ-treated rats these indices of direct toxic damage did not differ significantly from the control values. In lung tissue, AD induced oxidative stress measured by malondialdehyde content and fibrosis assessed by the hydroxyproline level. AMFJ prevented these effects of AD. In rat serum, AD caused a significant elevation of interleukin IL-6 on days 3 and 5, and a decrease of IL-10 on day 3. In AMFJ-treated rats, these indices of inflammation had values that did not differ significantly from the control ones.

conclusionAMFJ could have a protective effect against AD-induced pulmonary toxicity as evidenced by the reduced signs of AD-induced direct toxic damage, oxidative stress, inflammation, and fibrosis.

Indexed as

amiodaroneAronia melanocarpapneumotoxicityrats

Identifiers

PMID24914278
PMCPMC4048559
OpenAlexW2098197882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.