Evidence map›Paper›PMID 24914218›Full record

ArticleInfection and immunity2014

Substrate binding protein SBP2 of a putative ABC transporter as a novel vaccine antigen of Moraxella catarrhalis.

Taketo Otsuka, Charmaine Kirkham, Antoinette Johnson, Megan M Jones, Timothy F Murphy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Prevalence ofInterdisciplinary perspectives on infectious diseases · 2022
    Article
  4. Review
  5. Review
  6. Article
  7. Panel 6: Vaccines.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2017
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Taketo OtsukaDivision of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
Charmaine KirkhamDivision of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
Antoinette JohnsonDivision of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
Megan M JonesClinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, USA.
Timothy F MurphyDivision of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, USA murphyt@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Moraxella catarrhalis: virulence-based preventionR01DC012200 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2012 to 2016
$1.8M
NIDCD NIH HHS DC012200NIDCD NIH HHS R01 DC012200
6 · The paper itself

Abstract

Moraxella catarrhalis is a common respiratory tract pathogen that causes otitis media in children and infections in adults with chronic obstructive pulmonary disease. Since the introduction of the pneumococcal conjugate vaccines with/without protein D of nontypeable Haemophilus influenzae, M. catarrhalis has become a high-priority pathogen in otitis media. For the development of antibacterial vaccines and therapies, substrate binding proteins of ATP-binding cassette transporters are important targets. In this study, we identified and characterized a substrate binding protein, SBP2, of M. catarrhalis. Among 30 clinical isolates tested, the sbp2 gene sequence was highly conserved. In 2 different analyses (whole-cell enzyme-linked immunosorbent assay and flow cytometry), polyclonal antibodies raised to recombinant SBP2 demonstrated that SBP2 expresses epitopes on the bacterial surface of the wild type but not the sbp2 mutant. Mice immunized with recombinant SBP2 showed significantly enhanced clearance of M. catarrhalis from the lung compared to that in the control group at both 25-μg and 50-μg doses (P < 0.001). We conclude that SBP2 is a novel, attractive candidate as a vaccine antigen against M. catarrhalis.

Indexed as

AdultAnimalsAntigens, BacterialATP-Binding Cassette TransportersBacterial VaccinesCarrier ProteinsDisease Models, AnimalHumansLungMiceMice, Inbred BALB CMoraxella catarrhalisMoraxellaceae InfectionsVaccines, SyntheticAntigens, BacterialATP-Binding Cassette TransportersBacterial VaccinesCarrier ProteinsVaccines, Synthetic

Identifiers

PMID24914218
PMCPMC4136220
OpenAlexW1968533905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.