ArticleJournal of bacteriology2014
Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- A 2-pyridone amide inhibitor of transcriptional activity inAntimicrobial agents and chemotherapy · 2023Article
- Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency.ACS omega · 2023Article
- Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.FEBS letters · 2021Article
- Article
- GrgA overexpression inhibits Chlamydia trachomatis growth through sigmaMicrobial pathogenesis · 2021Article
- Inhibitory Activity of Pyrroloisoxazolidine Derivatives againstBioMed research international · 2021Article
- Optimal cultivation of Chlamydia requires testing of serum on individual species.BMC research notes · 2020Article
- Nonspecific toxicities of Streptococcus pyogenes and Staphylococcus aureus dCas9 in Chlamydia trachomatis.Pathogens and disease · 2019Article
- GrgA as a potential target of selective antichlamydials.PloS one · 2019Article
- Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth.Antimicrobial agents and chemotherapy · 2018Article
- Red FluorescentFrontiers in microbiology · 2018Article
- Antichlamydial Dimeric Indole Derivatives from Marine Actinomycete Rubrobacter radiotolerans.Planta medica · 2017Article
- Article
- Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.PloS one · 2015Article
- Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.Current clinical microbiology reportsReview
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Chlamydiae are widespread Gram-negative pathogens of humans and animals. Salicylidene acylhydrazides, developed as inhibitors of type III secretion system (T3SS) in Yersinia spp., have an inhibitory effect on chlamydial infection. However, these inhibitors also have the capacity to chelate iron, and it is possible that their antichlamydial effects are caused by iron starvation. Therefore, we have explored the modification of salicylidene acylhydrazides with the goal to uncouple the antichlamydial effect from iron starvation. We discovered that benzylidene acylhydrazides, which cannot chelate iron, inhibit chlamydial growth. Biochemical and genetic analyses suggest that the derivative compounds inhibit chlamydiae through a T3SS-independent mechanism. Four single nucleotide polymorphisms were identified in a Chlamydia muridarum variant resistant to benzylidene acylhydrazides, but it may be necessary to segregate the mutations to differentiate their roles in the resistance phenotype. Benzylidene acylhydrazides are well tolerated by host cells and probiotic vaginal Lactobacillus species and are therefore of potential therapeutic value.
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