ArticleSchizophrenia bulletin2015
Progressive reduction of visual P300 amplitude in patients with first-episode schizophrenia: an ERP study.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.Biological psychiatry · 2026Article
- Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia.PLoS biology · 2024Article
- P300 in schizophrenia: Then and now.Biological psychology · 2024Review
- Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents.BMC psychiatry · 2023Article
- The emotional facial recognition performance of Chinese patients with schizophrenia: An event-related potentials study.Indian journal of psychiatry · 2023Article
- Application of Machine Learning to Diagnostics of Schizophrenia Patients Based on Event-Related Potentials.Diagnostics (Basel, Switzerland) · 2023Article
- Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning.Journal of clinical medicine · 2021Article
- Longitudinal evaluation of visual P300 amplitude in clinical high-risk subjects: An event-related potential study.Psychiatry and clinical neurosciences · 2020Article
- Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study.Frontiers in psychiatry · 2020Article
- Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems.Frontiers in psychiatry · 2020Article
- Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300.Schizophrenia bulletin · 2019Article
- Nonlinear dynamics underlying sensory processing dysfunction in schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Single-Trial Mechanisms Underlying Changes in Averaged P300 ERP Amplitude and Latency in Military Service Members After Combat Deployment.Frontiers in human neuroscience · 2019Article
- Impaired conscious access and abnormal attentional amplification in schizophrenia.NeuroImage. Clinical · 2018Article
- Developmental trajectory of mismatch negativity and visual event-related potentials in healthy controls: Implications for neurodevelopmental vs. neurodegenerative models of schizophrenia.Schizophrenia research · 2018Article
- Functional connectivity when detecting rare visual targets in schizophrenia.Psychiatry research. Neuroimaging · 2017Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo understand the underlying dynamic neurophysiological changes over the course of schizophrenia, it is important to study subjects longitudinally from the early stage of the illness. We previously reported that visual P300 was already impaired in patients with first-episode schizophrenia (FESZ). This study demonstrates how the visual P300, as well as earlier components P1, N1, and N200, changed at the 1-year follow-up after their initial measurement.
methodsVisual ERPs were recorded with the same experimental paradigm and acquisition protocol at both time points in FESZ (n = 18) and healthy comparison subjects (n = 24). Participants silently counted infrequent target stimuli ("x") amid standard stimuli ("y") presented on the screen while the 64-channel electroencephalogram was recorded.
resultsFESZ showed smaller visual P300, N200, P1 (trend level) amplitude and delayed P300 and N1 latency at both time points; however, only P300 showed progressive amplitude reduction over the course of the illness at 1-year follow-up. P300 latency did not change over time in either group. FESZ showed significantly reduced Spatial Span total score at both time points, and there was a significant negative correlation between P300 peak amplitude and the Brief Psychiatric Rating Scale positive symptom score at baseline.
conclusionThese data show progressive P300 amplitude reduction in response to visual stimuli in the early stage of schizophrenia. These visual P300 findings support the concept of progression of schizophrenia, suggesting the usefulness of the visual P300 as a biological marker of progression.
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