ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Opportunities and challenges for time-resolved studies of protein structural dynamics at X-ray free-electron lasers.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Wavefront sensing at a high-repetition-rate X-ray free-electron laser.Journal of synchrotron radiation · 2026Article
- Temporal ghost imaging for pump-probe X-ray solution scattering.Acta crystallographica. Section A, Foundations and advances · 2025Article
- X-ray Absorption Spectroscopy of Dilute Metalloenzymes at X-ray Free-Electron Lasers in a Shot-by-Shot Mode.The journal of physical chemistry letters · 2025Article
- Deconvolution of dynamic heterogeneity in protein structure.Structural dynamics (Melville, N.Y.) · 2024Review
- Room temperature crystallography and X-ray spectroscopy of metalloenzymes.Methods in enzymology · 2023Article
- Mapping Enzyme Landscapes by Time-Resolved Crystallography with Synchrotron and X-Ray Free Electron Laser Light.Annual review of biophysics · 2022Review
- Room temperature XFEL crystallography reveals asymmetry in the vicinity of the two phylloquinones in photosystem I.Scientific reports · 2021Article
- Electron Diffraction of Ionic Argon Nanoclusters Embedded in Superfluid Helium Droplets.The journal of physical chemistry letters · 2021Article
- Using photocaging for fast time-resolved structural biology studies.Acta crystallographica. Section D, Structural biology · 2021Review
- Synchronous RNA conformational changes trigger ordered phase transitions in crystals.Nature communications · 2021Article
- Inter-Subunit Dynamics Controls Tunnel Formation During the Oxygenation Process in Hemocyanin Hexamers.Frontiers in molecular biosciences · 2021Article
- Electron diffraction of CSThe Journal of chemical physics · 2020Article
- Structural basis of light-harvesting in the photosystem II core complex.Protein science : a publication of the Protein Society · 2020Review
- Electron Diffraction of Pyrene Nanoclusters Embedded in Superfluid Helium Droplets.The journal of physical chemistry letters · 2020Article
- Advances in methods for atomic resolution macromolecular structure determination.F1000Research · 2020Review
- A shared vision for macromolecular crystallography over the next five years.Structural dynamics (Melville, N.Y.) · 2019Article
- Selection of Biophysical Methods for Characterisation of Membrane Proteins.International journal of molecular sciences · 2019Review
- Strategies for sample delivery for femtosecond crystallography.Acta crystallographica. Section D, Structural biology · 2019Review
- Hydration facilitates oxygenation of hemocyanin: perspectives from molecular dynamics simulations.European biophysics journal : EBJ · 2018Article
- Article
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Abstract
X-ray free-electron lasers (XFELs) are revolutionary X-ray sources. Their time structure, providing X-ray pulses of a few tens of femtoseconds in duration; and their extreme peak brilliance, delivering approximately 10(12) X-ray photons per pulse and facilitating sub-micrometre focusing, distinguish XFEL sources from synchrotron radiation. In this opinion piece, I argue that these properties of XFEL radiation will facilitate new discoveries in life science. I reason that time-resolved serial femtosecond crystallography and time-resolved wide angle X-ray scattering are promising areas of scientific investigation that will be advanced by XFEL capabilities, allowing new scientific questions to be addressed that are not accessible using established methods at storage ring facilities. These questions include visualizing ultrafast protein structural dynamics on the femtosecond to picosecond time-scale, as well as time-resolved diffraction studies of non-cyclic reactions. I argue that these emerging opportunities will stimulate a renaissance of interest in time-resolved structural biochemistry.
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