ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2014
Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2021Pooled it
- Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2020Pooled it
- Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa.Human vaccines & immunotherapeutics · 2019Trial
- Rationale for Recommending Varicella Vaccination Into the Swedish National Immunisation Programme.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Adverse events following measles, mumps, rubella and varicella virus vaccine live (PROQUADVirology journal · 2025Article
- No Increased Risk of Autoimmune Diseases Following HPV Vaccination: A Systematic Review and Meta-Analysis.Vaccines · 2025Review
- SMS-Based Active Surveillance of Adverse Events following Immunization in Children: The VigiVax Study.Vaccines · 2024Article
- Adverse events following Measles-Mumps-Rubella and varicella immunization: A safety profile analysis and comparison of different vaccination schedules based on the Italian Pharmacovigilance Network in the Veneto Region.Preventive medicine reports · 2024Article
- Febrile Seizures and Measles-Containing Vaccines in China: A Self-Controlled Case Series Study.Vaccines · 2021Article
- Assessing safety of Ontario's publicly funded MMR and MMRV immunization programs, 2012 to 2016.Paediatrics & child health · 2020Article
- Adverse events following measles-mumps-rubella-varicella vaccine: an independent perspective on Italian pharmacovigilance data.F1000Research · 2020Article
- Article
- Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany.International journal of environmental research and public health · 2018Review
- Risk of seizures after immunization in children with epilepsy: a risk interval analysis.BMC pediatrics · 2018Article
- Benefit Versus Risk Assessment of Rotavirus Vaccination in France: A Simulation and Modeling Analysis.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2018Article
- Febrile seizures: an overview.Drugs in context · 2018Review
- The Influence of Vaccine on Febrile Seizure.Current neuropharmacology · 2018Review
- Evaluation of Combination Measles-Mumps-Rubella-Varicella Vaccine Introduction in Australia.JAMA pediatrics · 2017Article
- Article
- Prophylactic antipyretics for prevention of febrile seizures following vaccination.Canadian family physician Medecin de famille canadien · 2017Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe combination measles-mumps-rubella-varicella (MMRV) vaccine currently used in Canada (Priorix-Tetra) may increase the risk of febrile seizures relative to the separate vaccines (MMR and varicella) previously administered. We determined the risk of febrile seizure after the first dose of MMRV, as well as any additional risk for children at high risk for seizures because of pre-existing medical conditions.
methodsIn this retrospective, population-based cohort study, we compared the risk of seizures after the first dose of MMRV with the risk after same-day administration of separate MMR and varicella vaccines (MMR+V) in children 12 to 23 months of age in the province of Alberta. We deterministically linked vaccination data to health service utilization data for seizures. We used Poisson regression, with adjustment for age and calendar year, to determine the risk for the full cohort and for high-risk children.
resultsThe risk of seizures 7 to 10 days after vaccination was twice as high with MMRV as with MMR+V (relative risk [RR] 1.99, 95% confidence interval [CI] 1.30-3.05). The excess absolute risk of seizures was 3.52 seizures per 10 000 doses of MMRV relative to MMR+V. In high-risk children, the risk was not differentially higher for MMRV (RR 1.30, 95% CI 0.60-2.79).
interpretationDespite an increased risk of febrile seizures following MMRV (compared with MMR+V), the absolute level of risk was small. Policy-makers need to balance these findings with the potential benefits of administering the combination vaccine or determine whether the choice of vaccine rests with clinicians and/or parents.
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