ArticleThe Journal of general virology2014
Evolutionary genetics of genotype H1 measles viruses in China from 1993 to 2012.
Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative study on molecular epidemiology of measles H1 outbreak and sporadic cases in Shandong Province, 2013-2019.BMC genomics · 2022Article
- Epidemiological Investigation and Virus Tracing of a Measles Outbreak in Zhoushan Islands, China, 2019.Frontiers in public health · 2020Article
- Phylogenetic and Epidemiological Analysis of Measles Viruses in Shenzhen, China from January 2015 to July 2019.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Measles, the need for a paradigm shift.European journal of epidemiology · 2019Review
- Nationwide Molecular Epidemiology of Measles Virus in Japan Between 2008 and 2017.Frontiers in microbiology · 2019Article
- The importance of serological and molecular analyses for the diagnosis of measles cases and for meeting elimination targets in Turkey from 2007 to 2015.Epidemiology and infection · 2018Article
- Importance of real-time RT-PCR to supplement the laboratory diagnosis in the measles elimination program in China.PloS one · 2018Article
- Evolutionary analysis of mumps viruses of genotype F collected in mainland China in 2001-2015.Scientific reports · 2017Article
- Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique.Science China. Life sciences · 2017Article
- PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.Journal of virology · 2016Article
- Genetic characterization of measles virus in the Philippines, 2008-2011.BMC research notes · 2015Article
- The first outbreak of measles virus caused by imported genotype D8 in Jiangsu province of China.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virologic surveillance is a critical component of measles management. One of the criteria for verification of elimination of endemic measles is genetic analysis of wild-type viruses to demonstrate lack of an indigenous genotype. Measles is yet to be eliminated in China, and genotype H1 has been detected continuously since virologic surveillance was initiated in 1993. Virologic surveillance has been very active in China, providing a unique opportunity to conduct a detailed study of the evolution of a single, endemic genotype over a timespan of nearly two decades. Phylogenetic analysis performed on the 450 nt coding sequence for the C-terminal 150 amino acids of the nucleoprotein (N-450), fusion (F) gene and haemagglutinin (H) gene confirmed the continued circulation of genotype H1 viruses for 19 years. No evidence of selective pressure for the H protein was found. The substitution rates ranged from 0.75×10(-3) substitutions site(-1) year(-1) for H to 1.65×10(-3) substitutions site(-1) year(-1) for N-450. The time of most recent common ancestor (TMRCA) for genotype H1 was estimated as approximately 1985 (95 % highest probability density, 1979-1989). Finally, the overall diversity of measles sequences from China decreased from 2005 to 2012, coincident with a substantial decrease in measles cases. The results suggest that detailed evolutionary analyses should facilitate the documentation of eventual measles elimination in China. Moreover, the molecular approaches used in this study can be applied in other countries approaching measles elimination.
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