Observational studyCirculation2014
Cumulative radiation exposure and cancer risk estimation in children with heart disease.
Observational study in Circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03822442 (Cardiac MRI Increases Accuracy and Decreases Risk of Evaluation of Children With Cardiomyopathy and Cardiac Transplantation), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiac MRI Increases Accuracy and Decreases Risk of Evaluation of Children With Cardiomyopathy and Cardiac Transplantation
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk of Cancer in Patients with Congenital Heart Disease: A Systematic Review and Meta-Analysis.Cardiology · 2025Pooled it
- A systematic review and meta-analysis of randomized controlled trials comparing low-dose versus standard-dose computed tomography-guided lung biopsy.Journal of cardiothoracic surgery · 2024Pooled it
- Radiation Safety in Children With Congenital and Acquired Heart Disease: A Scientific Position Statement on Multimodality Dose Optimization From the Image Gently Alliance.JACC. Cardiovascular imaging · 2017Guideline
- Cumulative ionizing radiation exposure in pediatric patients with chronic diseases: a narrative review.Pediatric radiology · 2026Review
- Photon-counting detector computed tomography in thoracic oncology: revolutionizing tumor imaging through precision and detail.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Review
- Feasibility of Magnetic Resonance Imaging-Guided Pulmonary Artery Stenting in a Commercial Wide-Bore 0.55-T Scanner.JACC. Basic to translational science · 2026Article
- Incidence of Malignancy in Children After Cardiac Catheterization Within the First 8 Years of Life Between 1999 and 2013-A Single-Center Experience.Journal of clinical medicine · 2026Article
- Organ-level radiation dose estimations from cardiac catheterizations in neonates with tetralogy of Fallot.Radiation physics and chemistry (Oxford, England : 1993) · 2026Article
- Reduction of radiation exposure and preserved image quality using photon-counting detector cardiac computed tomography without electrocardiographic gating in children with congenital heart disease.European radiology · 2026Article
- Unexpected Malrotation in Patients with Congenital Heart Disease Undergoing Gastrostomy Tube Placement: Is Routine Preoperative Upper Gastrointestinal Series Imaging Necessary?Pediatric cardiology · 2025Article
- Demonstrating the use of population level data to investigate trends in the rate, radiation dose and cost of Computed Tomography across clinical groups: Are there any areas of concern?Journal of medical radiation sciences · 2025Observational
- Real-Time Assessment of Pulmonary Blood Flow in Pulmonary Vein Stenosis Using the Fluoroscopic Flow Calculator.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Radiation Exposure during Cardiac Interventions in Congenital Heart Defects: A Multicenter German Registry Analysis 2012-2020.The Thoracic and cardiovascular surgeon · 2025Article
- Patient and physician exposure to X-rays at pediatric interventional cardiology - from world to Poland.International journal of occupational medicine and environmental health · 2024Review
- Implementing Patient Protection Radiation Dose Alerts for Pediatric Cardiac Catheterization Examinations.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Cumulative Radiation Exposure and Lifetime Cancer Risk in Patients With Tetralogy of Fallot Requiring Early Intervention.JACC. Advances · 2024Article
- The burden of radiation exposure in congenital heart disease: the Italian cohort profile and bioresource collection in HARMONIC project.Italian journal of pediatrics · 2024Article
- Are radiographs overutilized in pediatric orthopaedic emergency room care?Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- CanCHD Study of Hematopoietic Cancers in Children With and Without Genetic Syndromes.Journal of the American Heart Association · 2024Article
- PICS/AEPC/APPCS/CSANZ/SCAI/SOLACI: Expert Consensus Statement on Cardiac Catheterization for Pediatric Patients and Adults With Congenital Heart Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundChildren with heart disease are frequently exposed to imaging examinations that use ionizing radiation. Although radiation exposure is potentially carcinogenic, there are limited data on cumulative exposure and the associated cancer risk. We evaluated the cumulative effective dose of radiation from all radiation examinations to estimate the lifetime attributable risk of cancer in children with heart disease. METHODS AND
resultsChildren ≤6 years of age who had previously undergone 1 of 7 primary surgical procedures for heart disease at a single institution between 2005 and 2010 were eligible for the study. Exposure to radiation-producing examinations was tabulated, and cumulative effective dose was calculated in millisieverts. These data were used to estimate lifetime attributable risk of cancer above baseline using the approach of the Committee on Biological Effects of Ionizing Radiation VII. The cohort included 337 children exposed to 13 932 radiation examinations. Conventional radiographs represented 92% of examinations, whereas cardiac catheterization and computed tomography accounted for 81% of cumulative exposure. Overall median cumulative effective dose was 2.7 mSv (range, 0.1-76.9 mSv), and the associated lifetime attributable risk of cancer was 0.07% (range, 0.001%-6.5%). Median lifetime attributable risk of cancer ranged widely depending on surgical complexity (0.006%-1.6% for the 7 surgical cohorts) and was twice as high in females per unit exposure (0.04% versus 0.02% per 1-mSv effective dose for females versus males, respectively; P<0.001).
conclusionsOverall radiation exposures in children with heart disease are relatively low; however, select cohorts receive significant exposure. Cancer risk estimation highlights the need to limit radiation dose, particularly for high-exposure modalities.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.