Evidence map›Paper›PMID 24913833›Full record

ArticlePsychiatry research2014

Paternal age of schizophrenia probands and endophenotypic differences from unaffected siblings.

James Schmeidler, Laura C Lazzeroni, Neal R Swerdlow, Rui P Ferreira, David L Braff, Monica E Calkins, Kristin S Cadenhead, Robert Freedman, Michael F Green, Tiffany A Greenwood and 15 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

James SchmeidlerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, Box 1230, New York, NY, USA.
Laura C LazzeroniDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Neal R SwerdlowDepartment of Psychiatry, University of California, San Diego, CA, USA.
Rui P FerreiraDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, Box 1230, New York, NY, USA.
David L BraffDepartment of Psychiatry, University of California, San Diego, CA, USA; VISN-22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA.
Monica E CalkinsDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, CA, USA.
Robert FreedmanDepartment of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA.
Michael F GreenDepartment of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA, USA; VA Greater Los Angeles Health Care System, Los Angeles, CA, USA.
Tiffany A GreenwoodDepartment of Psychiatry, University of California, San Diego, CA, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Gregory A LightDepartment of Psychiatry, University of California, San Diego, CA, USA; VISN-22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA.
Ann OlincyDepartment of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA.
Keith H NuechterleinDepartment of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Allen D RadantDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Larry J SeidmanMassachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA, USA.
Larry J SieverDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, Box 1230, New York, NY, USA; VISN-3 Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, New York, NY, USA.
William S StoneMassachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Harvard Medical School Department of Psychiatry, Boston, MA, USA.
Joyce SprockDepartment of Psychiatry, University of California, San Diego, CA, USA.
Catherine A SugarDepartment of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA, USA; VA Greater Los Angeles Health Care System, Los Angeles, CA, USA.
Debby W TsuangDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA; VISN-20 Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
Ming T TsuangDepartment of Psychiatry, University of California, San Diego, CA, USA.
Bruce I TuretskyDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Jeremy M SilvermanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai School, One Gustave L. Levy Place, Box 1230, New York, NY, USA; James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA. Electronic address: jeremy.silverman@mssm.edu.

Funding

The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
The Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2M
The Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1M
Genetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7M
The Genetics of Endophenotypes and SchizophreniaR01MH065707 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2013
$3.6M
The Genetics of Endophenotypes and SchizophreniaR01MH065562 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SEIDMAN, LARRY J · 2003 to 2007
$2.6M
The Genetics of Endophenotypes and SchizophreniaR01MH065588 · NIMH · UNIVERSITY OF COLORADO DENVER · PI OLINCY, ANN · 2003 to 2007
$2.2M
6/6 - The Genetics of Endophenotypes and SchizophreniaR01MH086135 · NIMH · STANFORD UNIVERSITY · PI LAZZERONI, LAURA C. · 2010 to 2013
$1.3M
NIMH NIH HHS R01 MH042228NIMH NIH HHS R01MH042228NIMH NIH HHS R01 MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01 MH065562NIMH NIH HHS R01 MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01 MH065588NIMH NIH HHS R01 MH065707NIMH NIH HHS R01 MH086135NIMH NIH HHS R01MH086135NIMH NIH HHS R01MH65554NIMH NIH HHS R01MH65558NIMH NIH HHS R01MH65562NIMH NIH HHS R01MH65571NIMH NIH HHS R01MH65578NIMH NIH HHS R01MH65588NIMH NIH HHS R01MH65707
6 · The paper itself

Abstract

We evaluated the discrepancy of endophenotypic performance between probands with schizophrenia and unaffected siblings by paternal age at proband birth, a possible marker for de novo mutations. Pairs of schizophrenia probands and unaffected siblings (N=220 pairs) were evaluated on 11 neuropsychological or neurophysiological endophenotypes previously identified as heritable. For each endophenotype, the sibling-minus-proband differences were transformed to standardized scores. Then for each pair, the average discrepancy was calculated from its standardized scores. We tested the hypothesis that the discrepancy is associated with paternal age, controlling for the number of endophenotypes shared between proband and his or her sibling, and proband age, which were both associated with paternal age. The non-significant association between the discrepancy and paternal age was in the opposite direction from the hypothesis. Of the 11 endophenotypes only sensori-motor dexterity was significant, but in the opposite direction. Eight other endophenotypes were also in the opposite direction, but not significant. The results did not support the hypothesized association of increased differences between sibling/proband pairs with greater paternal age. A possible explanation is that the identification of heritable endophenotypes was based on samples for which schizophrenia was attributable to inherited rather than de novo/non-inherited causes.

Indexed as

Paternal AgeSiblingsAdultEndophenotypesFemaleHumansMaleMutationSchizophreniaCopy number variantsDe novo mutationsFamilial schizophreniaGenetic riskSporadic schizophrenia

Identifiers

PMID24913833
PMCPMC4110721

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