Evidence map›Paper›PMID 24913828›Full record

ReviewChromosoma2014

Emerging roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?

Luca Lo Piccolo, Davide Corona, Maria Cristina Onorati

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chromosoma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. From development to disease: the neuronal role of hnRNPs through the lens ofFrontiers in cell and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Amyotrophic Lateral Sclerosis Genes inInternational journal of molecular sciences · 2021
    Review
  9. An Interaction Network of RNA-Binding Proteins Involved inMolecular & cellular proteomics : MCP · 2020
    Article
  10. Over-expression of Hsp83 in grossly depletedJournal of biosciences · 2019
    Article
  11. Article
  12. Frontiers in genetics · 2019
    Review
  13. Modulation of the Hippo pathway and organ growth by RNA processing proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Luca Lo PiccoloDipartimento STEBICEF, Istituto Telethon Dulbecco c/o Universita' degli Studi di Palermo, 90128, Palermo, Italy, lucalopiccolo@gmail.com.
Davide Corona
Maria Cristina Onorati
University of Palermo · ITDulbecco Telethon Institute · IT

Funding

Telethon TCR09002
6 · The paper itself

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a highly conserved family of RNA-binding proteins able to associate with nascent RNAs in order to support their localization, maturation and translation. Research over this last decade has remarked the importance of gene regulatory processes at post-transcriptional level, highlighting the emerging roles of hnRNPs in several essential biological events. Indeed, hnRNPs are key factors in regulating gene expression, thus, having a number of roles in many biological pathways. Moreover, failure of the activities catalysed by hnRNPs affects various biological processes and may underlie several human diseases including cancer, diabetes and neurodegenerative syndromes. In this review, we summarize some of hnRNPs' roles in the model organism Drosophila melanogaster, particularly focusing on their participation in all aspects of post-transcriptional regulation as well as their conserved role and involvement in the aetiology of human pathologies.

Indexed as

RNA Processing, Post-TranscriptionalActive Transport, Cell NucleusAnimalsCell CompartmentationCell NucleusChromatinDrosophila melanogasterDrosophila ProteinsGene Expression RegulationHeredodegenerative Disorders, Nervous SystemHeterogeneous-Nuclear RibonucleoproteinsHumansProtein Processing, Post-TranslationalRNAChromatinDrosophila ProteinsHeterogeneous-Nuclear RibonucleoproteinsRNA

Identifiers

PMID24913828
OpenAlexW2010520098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.