ArticleJournal of experimental botany2014
2,4-Dichlorophenoxyacetic acid promotes S-nitrosylation and oxidation of actin affecting cytoskeleton and peroxisomal dynamics.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Microorganism-Driven 2,4-D Biodegradation: Current Status and Emerging Opportunities.Molecules (Basel, Switzerland) · 2024Review
- Cloning of the Arabidopsis SMAP2 promoter and analysis of its expression activity.Scientific reports · 2024Article
- Influence of Plant Growth Regulators on Glandular Trichome Density and Steviol Glycosides Accumulation inACS omega · 2022Article
- Cytotoxic and genotoxic effects of clopyralid herbicide on Allium cepa roots.Environmental science and pollution research international · 2021Article
- Peroxisomes as redox-signaling nodes in intracellular communication and stress responses.Plant physiology · 2021Review
- Main Molecular Pathways Associated with Copper Tolerance Response inPlants (Basel, Switzerland) · 2021Article
- Protein S-nitrosation differentially modulates tomato responses to infection by hemi-biotrophic oomycetes of Phytophthora spp.Horticulture research · 2021Article
- Jasmonates, Ethylene and Brassinosteroids Control Adventitious and Lateral Rooting as Stress Avoidance Responses to Heavy Metals and Metalloids.Biomolecules · 2021Review
- Nitric Oxide Alters the Pattern of Auxin Maxima and PIN-FORMED1 During Shoot Development.Frontiers in plant science · 2021Article
- Bundling up the Role of the Actin Cytoskeleton in Primary Root Growth.Frontiers in plant science · 2021Review
- Hydrogen sulfide (HaBIOTECH · 2021Review
- Hydrogen Sulfide Disturbs Actin Polymerization viaPlant physiology · 2018Article
- Salinity reduces 2,4-D efficacy in Echinochloa crusgalli by affecting redox balance, nutrient acquisition, and hormonal regulation.Protoplasma · 2018Article
- A Salutary Role of Reactive Oxygen Species in Intercellular Tunnel-Mediated Communication.Frontiers in cell and developmental biology · 2018Review
- Evidence for Brassinosteroid-Mediated PAT During Germination ofFrontiers in plant science · 2018Article
- Identification of S-Nitrosylated (SNO) Proteins inFrontiers in cellular and infection microbiology · 2017Article
- Peroxisomes Extend Peroxules in a Fast Response to Stress via a Reactive Oxygen Species-Mediated Induction of the Peroxin PEX11a.Plant physiology · 2016Article
- Article
- 2,4-D resistance in wild radish: reduced herbicide translocation via inhibition of cellular transport.Journal of experimental botany · 2016Article
- Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networks.Annals of botany · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2,4-Dichlorophenoxyacetic acid (2,4-D) is a synthetic auxin used as a herbicide to control weeds in agriculture. A high concentration of 2,4-D promotes leaf epinasty and cell death. In this work, the molecular mechanisms involved in the toxicity of this herbicide are studied by analysing in Arabidopsis plants the accumulation of reactive oxygen species (ROS) and nitric oxide (NO), and their effect on cytoskeleton structure and peroxisome dynamics. 2,4-D (23 mM) promotes leaf epinasty, whereas this process was prevented by EDTA, which can reduce ·OH accumulation. The analysis of ROS accumulation by confocal microscopy showed a 2,4-D-dependent increase in both H2O2 and O2·(-), whereas total NO was not affected by the treatment. The herbicide promotes disturbances on the actin cytoskeleton structure as a result of post-translational modification of actin by oxidation and S-nitrosylation, which could disturb actin polymerization, as suggested by the reduction of the F-actin/G-actin ratio. These effects were reduced by EDTA, and the reduction of ROS production in Arabidopsis mutants deficient in xanthine dehydrogenase (Atxdh) gave rise to a reduction in actin oxidation. Also, 2,4-D alters the dynamics of the peroxisome, slowing the speed and shortening the distances by which these organelles are displaced. It is concluded that 2,4-D promotes oxidative and nitrosative stress, causing disturbances in the actin cytoskeleton, thereby affecting the dynamics of peroxisomes and some other organelles such as the mitochondria, with xanthine dehydrogenase being involved in ROS production under these conditions. These structural changes in turn appear to be responsible for the leaf epinasty.
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