ReviewBest practice & research. Clinical gastroenterology2014
Genetic studies of Crohn's disease: past, present and future.
Review in Best practice & research. Clinical gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03291743 (The Biologic Onset of Crohn's Disease), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- A systematic review and functional bioinformatics analysis of genes associated with Crohn's disease identify more than 120 related genes.BMC genomics · 2022Pooled it
- Crohn's Disease in Malaysia: Could Application of the Precautionary Principle Reduce Future Incidence?Microorganisms · 2026Review
- Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study.Scientific reports · 2025Article
- Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn's Disease.Nutrients · 2024Review
- Persistent dysbiosis of duodenal microbiota in patients with controlled pediatric Crohn's disease after resolution of inflammation.Scientific reports · 2024Article
- Heterozygous variants ofHeliyon · 2024Article
- Characteristics of the gut microbiota and the effect ofFrontiers in microbiology · 2024Article
- The role of goblet cells and mucus in intestinal homeostasis.Nature reviews. Gastroenterology & hepatology · 2022Review
- The spatial transcriptomic landscape of the healing mouse intestine following damage.Nature communications · 2022Article
- Review
- DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.The Journal of clinical investigation · 2021Article
- IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease.International journal of colorectal disease · 2021Article
- Risk of Inflammatory Bowel Disease Following Appendectomy in Adulthood.Frontiers in medicine · 2021Article
- Article
- Growth and Puberty in Children with Inflammatory Bowel Diseases.Biomedicines · 2020Review
- Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil.World journal of gastroenterology · 2020Article
- Whole-Genome DNA Methylation Profiling of CD14+ Monocytes Reveals Disease Status and Activity Differences in Crohn's Disease Patients.Journal of clinical medicine · 2020Article
- Nutrition, IBD and Gut Microbiota: A Review.Nutrients · 2020Review
- Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective.International journal of molecular sciences · 2019Article
- Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science.Cells · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The exact aetiology of Crohn's disease is unknown, though it is clear from early epidemiological studies that a combination of genetic and environmental risk factors contributes to an individual's disease susceptibility. Here, we review the history of gene-mapping studies of Crohn's disease, from the linkage-based studies that first implicated the NOD2 locus, through to modern-day genome-wide association studies that have discovered over 140 loci associated with Crohn's disease and yielded novel insights into the biological pathways underlying pathogenesis. We describe on-going and future gene-mapping studies that utilise next generation sequencing technology to pinpoint causal variants and identify rare genetic variation underlying Crohn's disease risk. We comment on the utility of genetic markers for predicting an individual's disease risk and discuss their potential for identifying novel drug targets and influencing disease management. Finally, we describe how these studies have shaped and continue to shape our understanding of the genetic architecture of Crohn's disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.