Evidence map›Paper›PMID 24913269›Full record

ArticleVeterinary pathology2015

Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio).

T K Cooper, K N Murray, S Spagnoli, J M Spitsbergen

Open access · bronzeAbstract read
In one paragraph

Article in Veterinary pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. TheAutophagy · 2019
    Article
  7. Coccygeal chordoma in a degu: case report and review of the literature.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019
    Article
  8. Multiple primary chordomas of the lung.Respiratory medicine case reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

T K CooperDepartments of Comparative Medicine and Pathology, Penn State Hershey Medical Center, Hershey, PA, USA tcooper@hmc.psu.edu.
K N MurrayPathology and Health Services, Zebrafish International Resource Center, Eugene, OR, USA.
S SpagnoliPathology and Health Services, Zebrafish International Resource Center, Eugene, OR, USA Department of Environmental Health Sciences. Oregon State University, Corvallis, OR, USA.
J M SpitsbergenDepartment of Microbiology, Oregon State University, Corvallis, OR, USA.
Oregon State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Zebrafish International Resource Center (ZIRC)P40OD011021 · OD · UNIVERSITY OF OREGON · PI Zoltan Marton Varga · 2012 to 2026
$36.0M
ZEBRAFISH INTERNATIONAL RESOURCE CENTERP40RR012546 · NCRR · UNIVERSITY OF OREGON · PI WESTERFIELD, MONTE · 1998 to 2011
$21.9M
Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
Adult genome-wide phenotypic analysis of molecularly defined mutant genesR01HD069321 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI MULLINS, MARY C. · 2011 to 2015
$3.1M
PILOT--EFFECT OF TEMPERATURE ACCLIMATION ON PEROXISOMES OF TROUTP30ES003850 · NIEHS · OREGON STATE UNIVERSITY · PI WILLIAMS, DAVID E. · 1988 to 2006
$2.8M
Zebrafish Carcinogenesis and Cytochrome P450 ExpressionR01ES011587 · NIEHS · OREGON STATE UNIVERSITY · PI BUHLER, DONALD R · 2001 to 2004
$1.1M
MUTANT LINES OF ZEBRAFISH HIGHLY SENSITIVE TO NEOPLASIAR21ES013124 · NIEHS · OREGON STATE UNIVERSITY · PI SPITSBERGEN, JAN M · 2004 to 2005
$283k
NCRR NIH HHS 3P40RR12546NCRR NIH HHS 3P40RR12546-03S1NCRR NIH HHS P40 RR012546NICHD NIH HHS R01 HD069321NIEHS NIH HHS P30 ES000210NIEHS NIH HHS P30ES00210NIEHS NIH HHS P30 ES003850NIEHS NIH HHS R01 ES011587NIEHS NIH HHS R01ES011587NIEHS NIH HHS R21 ES013124NIEHS NIH HHS R21ES013124NIH HHS P40 OD011021PHS HHS P30ESO3850
6 · The paper itself

Abstract

Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.

Indexed as

AnimalsChordomaFemaleFish DiseasesIntestinal NeoplasmsMaleSpinal NeoplasmsZebrafishchordomasintestinalvertebralzebrafish

Identifiers

PMID24913269
PMCPMC4261063
OpenAlexW2129925719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.