Evidence map›Paper›PMID 24913176›Full record

ArticleAntimicrobial agents and chemotherapy2014

Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation.

Nicolas Delattin, Katrijn De Brucker, David J Craik, Olivier Cheneval, Barbara De Coninck, Bruno P A Cammue, Karin Thevissen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intestinal Infection ofFrontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicolas DelattinCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Katrijn De BruckerCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
David J CraikInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Olivier ChenevalInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Barbara De ConinckCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
Bruno P A CammueCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium Department of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, Ghent, Belgium bruno.cammue@biw.kuleuven.be.
Karin ThevissenCentre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.

Funding

Contact sensing and C. albicans-host interactionR01AI081794 · NIAID · TUFTS UNIVERSITY BOSTON · PI KUMAMOTO, CAROL A. · 2010 to 2014
$2.2M
NIAID NIH HHS R01 AI081794NIAID NIH HHS R01AI081794
6 · The paper itself

Abstract

We performed a structure-activity relationship study of the antibiofilm plant-derived decapeptide OSIP108. Introduction of positively charged amino acids R, H, and K resulted in an up-to-5-fold-increased antibiofilm activity against Candida albicans compared to native OSIP108, whereas replacement of R9 resulted in complete abolishment of its antibiofilm activity. By combining the most promising amino acid substitutions, we found that the double-substituted OSIP108 analogue Q6R/G7K had an 8-fold-increased antibiofilm activity.

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAntifungal AgentsArabidopsisArabidopsis ProteinsArginineBiofilmsCandida albicansHistidineLysineMicrobial Sensitivity TestsMolecular Sequence DataStatic ElectricityStructure-Activity RelationshipAntifungal AgentsArabidopsis ProteinsArginineHistidineLysinemethionyl-leucyl-cysteinyl-valyl-leucyl-glutaminyl-glycyl-leucyl-arginyl-glutamic acid

Identifiers

PMID24913176
PMCPMC4135999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.