Evidence map›Paper›PMID 24913170›Full record

ArticleAntimicrobial agents and chemotherapy2014

Identification of a novel clone, ST736, among Enterococcus faecium clinical isolates and its association with daptomycin nonsusceptibility.

Guiqing Wang, Sitharthan Kamalakaran, Abhay Dhand, Weihua Huang, Caroline Ojaimi, Jian Zhuge, Leslie Lee Yee, Pramod Mayigowda, Pavan Kumar Makam Surendraiah, Nevenka Dimitrova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Emergence and Transmission of Daptomycin and Vancomycin-Resistant Enterococci Between Patients and Hospital Rooms.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guiqing WangDepartment of Pathology, New York Medical College, Valhalla, New York, USA Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, New York, USA guiqing_wang@nymc.edu.
Sitharthan KamalakaranPhilips Research North America, Briarcliff Manor, New York, USA.
Abhay DhandDepartment of Medicine, New York Medical College, Valhalla, New York, USA.
Weihua HuangDepartment of Pathology, New York Medical College, Valhalla, New York, USA.
Caroline OjaimiDepartment of Pathology, New York Medical College, Valhalla, New York, USA.
Jian ZhugeDepartment of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, New York, USA.
Leslie Lee YeeDepartment of Pharmacy, Westchester Medical Center, Valhalla, New York, USA.
Pramod MayigowdaPhilips Research North America, Briarcliff Manor, New York, USA.
Pavan Kumar Makam SurendraiahDepartment of Pathology, New York Medical College, Valhalla, New York, USA.
Nevenka DimitrovaPhilips Research North America, Briarcliff Manor, New York, USA.
John T FallonDepartment of Pathology, New York Medical College, Valhalla, New York, USA Department of Medicine, New York Medical College, Valhalla, New York, USA Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, we assessed the population genetics of daptomycin-nonsusceptible Enterococcus faecium (DNSE) clinical isolates by multilocus sequence typing (MLST) and whole-genome sequencing analysis. Forty-two nonduplicate DNSE isolates and 43 randomly selected daptomycin-susceptible E. faecium isolates were included in the analysis. All E. faecium isolates were recovered from patients at a tertiary care medical center in suburban New York City from May 2009 through December 2013. The daptomycin MICs of the DNSE isolates ranged from 6 to >256 μg/ml. Three major clones of E. faecium (ST18, ST412, and ST736) were identified among these clinical isolates by MLST and whole-genome sequence-based analysis. A newly recognized clone, ST736, was seen in 32 of 42 (76.2%) DNSE isolates and in only 14 of 43 (32.6%) daptomycin-susceptible E. faecium isolates (P < 0.0001). This report provides evidence of the association between E. faecium clone ST736 and daptomycin nonsusceptibility. The identification and potential spread of this novel E. faecium clone and its association with daptomycin nonsusceptibility constitute a challenge for patient management and infection control at our medical center.

Indexed as

Genome, BacterialAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsChildClone CellsDaptomycinDrug Resistance, BacterialEnterococcus faeciumFemaleGram-Positive Bacterial InfectionsHumansMaleMicrobial Sensitivity TestsAnti-Bacterial AgentsDaptomycin

Identifiers

PMID24913170
PMCPMC4136069

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.