Evidence map›Paper›PMID 24913165›Full record

ArticleAntimicrobial agents and chemotherapy2014

Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Meredith S Wright, Federico Perez, Lauren Brinkac, Michael R Jacobs, Keith Kaye, Eric Cober, David van Duin, Steven H Marshall, Andrea M Hujer, Susan D Rudin and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Differential virulence potential of different clades of multidrug-resistantmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Molecular Analysis ofmSphere · 2021
    Article
  6. Emerging carbapenem-resistantMicrobial genomics · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. First clinical case of KPC-3-producingNew microbes and new infections · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. SmallFrontiers in microbiology · 2019
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Meredith S WrightJ. Craig Venter Institute, La Jolla, California, USA.
Federico PerezResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Lauren BrinkacJ. Craig Venter Institute, La Jolla, California, USA.
Michael R JacobsDepartment of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Keith KayeDetroit Medical Center, Detroit, Michigan, USA.
Eric CoberInfectious Diseases Department, Cleveland Clinic, Cleveland, Ohio, USA.
David van DuinDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Steven H MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Andrea M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Susan D RudinResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Kristine M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA madams@jcvi.org Robert.Bonomo@va.gov.
Mark D AdamsJ. Craig Venter Institute, La Jolla, California, USA madams@jcvi.org Robert.Bonomo@va.gov.
Louis Stokes Cleveland VA Medical Center · USJ. Craig Venter Institute · USCase Western Reserve University · USCleveland Clinic · USDetroit Medical Center · USUniversity Hospitals Case Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI SUTTON, GRANGER GIDEON · 2014 to 2018
$29.7M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
Evolution of multidrug resistance in Acinetobacter baumanniiR01GM094403 · NIGMS · J. CRAIG VENTER INSTITUTE, INC. · PI ADAMS, MARK D · 2011 to 2014
$1.3M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NCATS NIH HHS KL2 TR000440NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NIAID NIH HHS HHSN272200900007CNIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01AI072219NIAID NIH HHS U19 AI110819NIAID NIH HHS UM1 AI104681NIAID NIH HHS UM1AI104681NIGMS NIH HHS R01 GM094403NIGMS NIH HHS R01GM094403
6 · The paper itself

Abstract

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.

Indexed as

Anti-Bacterial AgentsBacterial Typing Techniquesbeta-Lactamasesbeta-Lactam ResistanceCarbapenemsHospitalsHumansKlebsiella InfectionsKlebsiella pneumoniaeMidwestern United StatesPhylogenyPlasmidsPolymorphism, Single NucleotidePolysaccharides, BacterialAnti-Bacterial Agentsbeta-LactamasesCarbapenemsPolysaccharides, Bacterial

Identifiers

PMID24913165
PMCPMC4136011
OpenAlexW2017404622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.