ReviewNature reviews. Cardiology2014
Cardiac imaging for assessment of left atrial appendage stasis and thrombosis.
Review in Nature reviews. Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Patients With Acute Ischemic Stroke (AIS of HEARTS).Stroke · 2026Pooled it
- Overcoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure.BMC cardiovascular disorders · 2024Pooled it
- Cardiac Computed Tomography Versus Transesophageal Echocardiography for the Detection of Left Atrial Appendage Thrombus: A Systemic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Left Atrial Appendage: Mere Spectator or Protagonist? A Narrative Review of Its Multimodal Imaging Assessment and Its Closure Techniques.Journal of clinical medicine · 2026Review
- A multivariable prediction model for left atrial appendage spontaneous echo contrast in patients with atrial fibrillation: development and external validation.BMC cardiovascular disorders · 2026Article
- Relationship Between Circulatory Stasis in the Left Atrial Appendage Detected by Cardiac Computed Tomography Angiography With Atrial Fibrillation Recurrence After Initial Catheter Ablation.Journal of the American Heart Association · 2026Observational
- Optimizing left atrial appendage imaging: the diagnostic value of left lateral decubitus cardiac CT angiography.Frontiers in cardiovascular medicine · 2026Article
- Cardiac CT for electrophysiological interventions.The international journal of cardiovascular imaging · 2025Review
- Machine-learning model for predicting left atrial thrombus in patients with paroxysmal atrial fibrillation.BMC cardiovascular disorders · 2025Article
- Article
- Multiphysics simulations reveal haemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics.The Journal of physiology · 2024Article
- Left Atrial Appendage Opacification on Cardiac Computed Tomography in Acute Ischemic Stroke: The Clinical Implications of Slow-Flow.Journal of the American Heart Association · 2024Article
- Associations between 3D-based Left Atrial Volumetric and Blood Flow Parameters in a Single-Site Cohort of the Multi-Ethnic Study of Atherosclerosis.Radiology. Cardiothoracic imaging · 2024Article
- Presence of Residual Cardiac Thrombus Predicts Poor Outcome in Cardioembolic Stroke After Reperfusion Therapy.Journal of the American Heart Association · 2024Article
- Preoperative diagnostic value of multimodal spectral CT for patients with atrial fibrillation undergoing radiofrequency ablation.Frontiers in medicine · 2024Article
- Diagnosis and Management of Atrial Fibrillation in Acute Ischemic Stroke in the Setting of Reperfusion Therapy: Insights and Strategies for Optimized Care.Journal of cardiovascular development and disease · 2023Review
- Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles.Nature communications · 2023Article
- Radiomics Based on Single-Phase CTA for Distinguishing Left Atrial Appendage Thrombus from Circulatory Stasis in Patients with Atrial Fibrillation before Ablation.Diagnostics (Basel, Switzerland) · 2023Article
- Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation.BMC cardiovascular disorders · 2023Article
- Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is the most-common arrhythmia in the elderly population (age >65 years). The left atrial appendage (LAA) is the main location of thrombus formation, predominantly in patients with nonvalvular AF. This Review is focused on the pathophysiology, assessment, and clinical implications of stasis (or spontaneous echocardiographic contrast; SEC) and thrombus formation in the LAA. The gold-standard modality for assessment of SEC and thrombus in the LAA is echocardiography, particularly transoesophageal echocardiography (TEE). Cardiac CT (CCT) is an accurate, noninvasive alternative to TEE for the detection of LAA thrombi, distinctly when delayed-imaging acquisition protocols are used. Prospective studies to validate the use of cardiac MRI (CMR) for this purpose are needed, and will avoid the need for radiation and iodinated contrast. CCT or CMR could potentially be implemented to rule out LAA thrombus, avoiding unnecessary preprocedural TEE. Cardiac imaging is also of primary importance in the setting of LAA closure devices and electrophysiological studies. New trials are needed to compare the various imaging modalities, with surgicopathological findings as a reference standard.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.