ArticleVirology journal2014
The placental specific gene, PLAC1, is induced by the Epstein-Barr virus and is expressed in human tumor cells.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prophylactic and therapeutic CSC-based vaccination reduced tumor growth, metastasis and enhanced survival in mouse model of breast cancer.Breast cancer research : BCR · 2026Article
- Identification of placenta-specific protein 1 (PLAC-1) expression on human PC-3 cell line-derived prostate cancer stem cells compared to the tumor parental cells.Discover oncology · 2024Article
- The potential value of cancer-testis antigens in ovarian cancer: Prognostic markers and targets for immunotherapy.Immunity, inflammation and disease · 2024Review
- PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer.Molecular medicine reports · 2021Article
- Review
- PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation.Oncotarget · 2020Article
- PLAC1: biology and potential application in cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2019Review
- Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets.Journal of ovarian research · 2019Review
- Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis.Scientific reports · 2018Article
- PLAC1 as a serum biomarker for breast cancer.PloS one · 2018Article
- Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer.Oncology reports · 2018Article
- Placenta-specific1 (PLAC1) is a potential target for antibody-drug conjugate-based prostate cancer immunotherapy.Scientific reports · 2017Article
- Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2017Article
- PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology.Prenatal diagnosis · 2010Review
- Expression of Human Placenta-specific 1 (PLAC1) in CHO-K1 Cells.Avicenna journal of medical biotechnologyArticle
- Investigation of Expression Profile of Placenta-specific 1 (PLAC1) in Acute Myeloid and Lymphoid Leukemias.Avicenna journal of medical biotechnologyArticle
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Epstein-Barr virus (EBV) is a causal agent in a number of malignancies in humans including hematopoietic tumors and non-hematopoietic tumors. Burkitt's lymphoma cell lines containing the Epstein-Barr virus have been shown to form tumors in nude mice while clonal derivatives of such cell lines in which the viral genome has been lost do not (JID 177: 1194-1201, 1998; JV 72: 9150-9156, 1998; JV 68: 6069-6073, 1994). The re-introduction of EBV into these EBV negative BLs reconstitutes the tumor phenotype. Thus, EBV-induced cellular genes play critical role in EBV-related tumors. METHODS AND
resultsIn an attempt to identify cellular genes regulated by EBV that may contribute to its tumorigenic properties, we have enforced genome loss in the Burkitt's lymphoma (BL) line, MutuI, by introducing a dominant negative form of the episomal replication factor, EBNA1 and carried out gene array analysis. One of the genes identified by this analysis is PLAC1, a gene originally identified as being expressed exclusively in placental tissue. Real time RT-PCR analysis verified higher expression in EBV positive vs. EBV negative Mutu clones. Analysis of a panel of RNAs from 20 normal tissues demonstrated the highest level of expression in placenta but significant expression was also observed in testis and brain cerebellum. PLAC1 expression was also observed in non-BL tumor cell lines derived from breast, ovary, and prostate. Lastly, expression of PLAC1 was found to be higher in some primary breast tumors compared to normal adjacent tissues.
conclusionThis data suggests that the EBV-induced PLAC1 is a member of the cancer/testis group of tumor antigens.
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