Trial reportBMJ (Clinical research ed.)2014
Effect of screening and lifestyle counselling on incidence of ischaemic heart disease in general population: Inter99 randomised trial.
Trial report in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 119 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Non-pharmacological Intervention Study for Prevention of Ischaemic Heart Disease Inter99
Twenty-year Follow-up of the Inter99 Cohort
Who cites it
119 citing papers in PubMed, 10 syntheses or guidelines pooled it, 264 citations in OpenAlex.
- Effectiveness and cost-effectiveness of general health checks in adults: A systematic review.BMC public health · 2026Pooled it
- Knowledge and perception of dementia risk and protective factors: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Stakeholders' perceptions and experiences of factors influencing the commissioning, delivery, and uptake of general health checks: a qualitative evidence synthesis.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Hierarchies of evidence applied to lifestyle Medicine (HEALM): introduction of a strength-of-evidence approach based on a methodological systematic review.BMC medical research methodology · 2019Pooled it
- General health checks in adults for reducing morbidity and mortality from disease.The Cochrane database of systematic reviews · 2019Pooled it
- Barriers and facilitators to participation in a health check for cardiometabolic diseases in primary care: A systematic review.European journal of preventive cardiology · 2018Pooled it
- Risk scoring for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2017Pooled it
- Guideline
- Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2016Pooled it
- Effect of a Community-Based Program to Accelerate Referral to Physicians for Individuals at High-Risk of Lifestyle-Related Diseases: A Cluster Randomized Trial.Journal of atherosclerosis and thrombosis · 2023Trial
- Evaluating the Effectiveness of Letter and Telephone Reminders in Promoting the Use of Specific Health Guidance in an At-Risk Population for Metabolic Syndrome in Japan: A Randomized Controlled Trial.International journal of environmental research and public health · 2023Trial
- Effects of a comprehensive lifestyle intervention on cardiovascular health: the TANSNIP-PESA trial.European heart journal · 2022Trial
- Effectiveness of the population-based 'check your health preventive programme' conducted in a primary care setting: a pragmatic randomised controlled trial.Journal of epidemiology and community health · 2022Trial
- Trial
- Cost-effectiveness of a stepwise cardiometabolic disease prevention program: results of a randomized controlled trial in primary care.BMC medicine · 2021Trial
- Lipidemic Profile Changes over a Two-Year Intervention Period: Who Benefited Most from the Feel4Diabetes Program?Nutrients · 2020Trial
- Trial
- Higher mortality in women living in high-participation areas of a population-based health check and lifestyle intervention study.International journal of public health · 2019Trial
- A health dialogue intervention reduces cardiovascular risk factor levels: a population based randomised controlled trial in Swedish primary care setting with 1-year follow-up.BMC public health · 2017Trial
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of systematic screening for risk factors for ischaemic heart disease followed by repeated lifestyle counselling on the 10 year development of ischaemic heart disease at a population level.
designRandomised controlled community based trial.
settingSuburbs of Copenhagen, Denmark.
participants59,616 people aged 30-60 years randomised with different age and sex randomisation ratios to an intervention group (n = 11,629) and a control group (n = 47,987).
interventionThe intervention group was invited for screening, risk assessment, and lifestyle counselling up to four times over a five year period. All participants with an unhealthy lifestyle had individually tailored lifestyle counselling at all visits (at baseline and after one and three years); those at high risk of ischaemic heart disease, according to predefined criteria, were furthermore offered six sessions of group based lifestyle counselling on smoking cessation, diet, and physical activity. After five years all were invited for a final counselling session. Participants were referred to their general practitioner for medical treatment, if relevant. The control group was not invited for screening.
main outcome measuresThe primary outcome measure was incidence of ischaemic heart disease in the intervention group compared with the control group. Secondary outcome measures were stroke, combined events (ischaemic heart disease, stroke, or both), and mortality.
results6091 (52.4%) people in the intervention group participated at baseline. Among 5978 people eligible at five year follow-up (59 died and 54 emigrated), 4028 (67.4%) attended. A total of 3163 people died in the 10 year follow-up period. Among 58,308 without a history of ischaemic heart disease at baseline, 2782 developed ischaemic heart disease. Among 58,940 without a history of stroke at baseline, 1726 developed stroke. No significant difference was seen between the intervention and control groups in the primary end point (hazard ratio for ischaemic heart disease 1.03, 95% confidence interval 0.94 to 1.13) or in the secondary endpoints (stroke 0.98, 0.87 to 1.11; combined endpoint 1.01, 0.93 to 1.09; total mortality 1.00, 0.91 to 1.09).
conclusionA community based, individually tailored intervention programme with screening for risk of ischaemic heart disease and repeated lifestyle intervention over five years had no effect on ischaemic heart disease, stroke, or mortality at the population level after 10 years.Trial registration Clinical trials NCT00289237.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.