SynthesisMolecular psychiatry2014
Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder.
Synthesis in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment and management of treatment-refractory obsessive-compulsive disorder in children.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Pooled it
- Hoarding Symptoms in Children and Adolescents With Obsessive-Compulsive Disorder: Clinical Features and Response to Cognitive-Behavioral Therapy.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview.World journal of clinical pediatrics · 2026Review
- An objective measure of insight in hoarding Disorder: Associations with severity, functioning, and neuropsychological performance.Journal of psychiatric research · 2026Article
- Stability and transition likelihood of primary symptoms in adults with obsessive-compulsive disorder: A 5-year prospective follow-up study.Journal of affective disorders · 2025Article
- Symptom Dimensions of Pediatric Obsessive-Compulsive Disorder: Exploratory Examination of Associations with Clinical Features and Response to Cognitive-Behavioral Therapy.Journal of obsessive-compulsive and related disorders · 2025Article
- Functional Analysis and Treatment of Hoarding in a Child with Autism Spectrum Disorder.Behavior analysis in practice · 2025Article
- Pediatric Treatment-Resistant Obsessive Compulsive Disorder: Treatment Options and Challenges.Paediatric drugs · 2024Review
- WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder.Neural regeneration research · 2022Review
- Development of a scale to assess obsessive-compulsive tendencies among Japanese university students.Heliyon · 2022Article
- The prefrontal cortex and OCD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway.Molecular psychiatry · 2022Review
- Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder.Psychiatry research · 2021Article
- Lithium: a potential therapeutic strategy in obsessive-compulsive disorder by targeting the canonical WNT/β pathway.Translational psychiatry · 2021Review
- Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder?Frontiers in psychiatry · 2021Article
- Response to Fluvoxamine in the Obsessive-Compulsive Disorder Patients: Bayesian Ordinal Quantile Regression.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
- Pharmacotherapeutic Strategies and New Targets in OCD.Current topics in behavioral neurosciences · 2021Review
- Functional connectivity of the raphe nucleus as a predictor of the response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Hoarding in children and adolescents with obsessive-compulsive disorder: prevalence, clinical correlates, and cognitive behavioral therapy outcome.European child & adolescent psychiatry · 2019Article
- Perceived emotion regulation and emotional distress tolerance in patients with hoarding disorder.Journal of obsessive-compulsive and related disorders · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
DSM-5 recognizes hoarding disorder as distinct from obsessive-compulsive disorder (OCD), codifying a new consensus. Hoarding disorder was previously classified as a symptom of OCD and patients received treatments designed for OCD. We conducted a meta-analysis to determine whether OCD patients with hoarding symptoms responded differently to traditional OCD treatments compared with OCD patients without hoarding symptoms. An electronic search was conducted for eligible studies in PubMed. A trial was eligible for inclusion if it (1) was a randomized controlled trial, cohort or case-control study; (2) compared treatment response between OCD patients with and those without hoarding symptoms, or examined response to treatment between OCD symptom dimensions (which typically include hoarding) and (3) examined treatment response to pharmacotherapy, behavioral therapy or their combination. Our primary outcome was differential treatment response between OCD patients with and those without hoarding symptoms, expressed as an odds ratio (OR). Twenty-one studies involving 3039 total participants including 304 with hoarding symptoms were included. Patients with OCD and hoarding symptoms were significantly less likely to respond to traditional OCD treatments than OCD patients without hoarding symptoms (OR=0.50 (95% confidence interval 0.42-0.60), z=-7.5, P<0.0001). This finding was consistent across treatment modalities. OCD patients with hoarding symptoms represent a population in need of further treatment research. OCD patients with hoarding symptoms may benefit more from interventions specifically targeting their hoarding symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.