ArticleJournal of the American Society for Mass Spectrometry2014
Energetics and kinetics of thermal ionization models of MALDI.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research.Analytical chemistry · 2019Article
- The Influence of MS Imaging Parameters on UV-MALDI Desorption and Ion Yield.Journal of the American Society for Mass Spectrometry · 2019Article
- Comment on: "Energetics and Kinetics of Thermal Ionization Models of MALDI" by Richard Knochenmuss. J. Am. Soc. Mass Spectrom. 25, 1521-1527 (2014).Journal of the American Society for Mass Spectrometry · 2015Article
- Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization.Journal of the American Society for Mass Spectrometry · 2015Article
- Ion-to-Neutral Ratios and Thermal Proton Transfer in Matrix-Assisted Laser Desorption/Ionization.Journal of the American Society for Mass Spectrometry · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermal models of ultraviolet MALDI ionization based on the polar fluid concept are re-examined. Key components are very high solvating power of the fluidized matrix and consequent low reaction-free energy, attainment of thermal equilibrium in the fluid, and negligible recombination losses. None of these are found to hold in a MALDI event. The reaction-free energy in the hot matrix must be near the gas phase value, ion formation is too slow to approach equilibrium, and geminate recombination of autoprotolysis pairs greatly increases the initial loss rate. The maximum thermal ion yield is estimated to be many orders of magnitude below experimental values.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.