ArticleProceedings of the National Academy of Sciences of the United States of America2014
Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 194 citations in OpenAlex.
- A cellular view of seed development and germination.The Plant cell · 2026Review
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- The role of geometry in morphogenesis.Development (Cambridge, England) · 2026Review
- Morphogenesis of moss leaf-like organs through variations in deeply shared developmental principles.Science advances · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Correlations between surface area and volume in cell size and growth in Arabidopsis thaliana.BMC plant biology · 2026Article
- Quantification of cell-type-specific plasmodesmata distribution in Arabidopsis roots reveals spatial and patterning dynamics.The Plant journal : for cell and molecular biology · 2026Article
- Mechanical interactions between tissue layers underlie plant morphogenesis.Nature plants · 2025Article
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity.Development (Cambridge, England) · 2024Article
- Establishment of single-cell transcriptional states during seed germination.Nature plants · 2024Article
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.Development (Cambridge, England) · 2024Article
- Hydrogel morphogenesis induced by force-controlled growth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- WOX2 functions redundantly with WOX1 and WOX4 to positively regulate seed germination in Arabidopsis.Planta · 2024Article
- Hidden functional complexity in the flora of an early land ecosystem.The New phytologist · 2024Article
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
- Role of turgor-pressure induced boundary tension in the maintenance of the shoot apical meristem ofJournal of the Royal Society, Interface · 2023Article
- A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth.NPJ systems biology and applications · 2023Article
- 3D cellular morphometrics of ovule primordium development inFrontiers in plant science · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
Morphogenesis occurs in 3D space over time and is guided by coordinated gene expression programs. Here we use postembryonic development in Arabidopsis plants to investigate the genetic control of growth. We demonstrate that gene expression driving the production of the growth-stimulating hormone gibberellic acid and downstream growth factors is first induced within the radicle tip of the embryo. The center of cell expansion is, however, spatially displaced from the center of gene expression. Because the rapidly growing cells have very different geometry from that of those at the tip, we hypothesized that mechanical factors may contribute to this growth displacement. To this end we developed 3D finite-element method models of growing custom-designed digital embryos at cellular resolution. We used this framework to conceptualize how cell size, shape, and topology influence tissue growth and to explore the interplay of geometrical and genetic inputs into growth distribution. Our simulations showed that mechanical constraints are sufficient to explain the disconnect between the experimentally observed spatiotemporal patterns of gene expression and early postembryonic growth. The center of cell expansion is the position where genetic and mechanical facilitators of growth converge. We have thus uncovered a mechanism whereby 3D cellular geometry helps direct where genetically specified growth takes place.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.