ArticleProceedings of the National Academy of Sciences of the United States of America2014
Identification of genes preventing transgenerational transmission of stress-induced epigenetic states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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Who cites it
72 citing papers in PubMed, 138 citations in OpenAlex.
- Heat stress responses of plants during adaptation to high temperature environments: A review of recent advances and insights.Plant signaling & behavior · 2026Review
- Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives.Plant, cell & environment · 2026Review
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- Plant defence priming and memory mechanisms under climate change.Essays in biochemistry · 2026Review
- Alternative splicing: an underexplored layer in immune receptor regulation, systemic resistance and priming.Frontiers in plant science · 2026Article
- A Brief Overview of the Epigenetic Regulatory Mechanisms in Plants.International journal of molecular sciences · 2025Review
- Vegetal memory through the lens of transcriptomic changes - recent progress and future practical prospects for exploiting plant transcriptional memory.Plant signaling & behavior · 2024Review
- Establishment and Maintenance of Heat-Stress Memory in Plants.International journal of molecular sciences · 2024Review
- A review of the potential involvement of small RNAs in transgenerational abiotic stress memory in plants.Functional & integrative genomics · 2024Review
- Genomic and Epigenomic Changes in the Progeny of Cold-StressedInternational journal of molecular sciences · 2024Article
- Role of Epigenetic Factors in Response to Stress and Establishment of Somatic Memory of Stress Exposure in Plants.Plants (Basel, Switzerland) · 2023Review
- Epigenetic Regulation During Plant Development and the Capacity for Epigenetic Memory.Annual review of plant biology · 2023Review
- TheFrontiers in plant science · 2023Article
- How do plants remember drought?Planta · 2022Review
- Abiotic stress responses in plants.Nature reviews. Genetics · 2022Review
- Molecular insights into mechanisms underlying thermo-tolerance in tomato.Frontiers in plant science · 2022Review
- Unravelling the Role of Epigenetic Modifications in Development and Reproduction of Angiosperms: A Critical Appraisal.Frontiers in genetics · 2022Review
- Comparative transcriptome and DNA methylation analysis in temperature-sensitive genic male sterile wheat BS366.BMC genomics · 2021Article
- Molecular mechanisms of plant tolerance to heat stress: current landscape and future perspectives.Plant cell reports · 2021Review
- The Dynamism of Transposon Methylation for Plant Development and Stress Adaptation.International journal of molecular sciences · 2021Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Examples of transgenerational transmission of environmentally induced epigenetic traits remain rare and disputed. Abiotic stress can release the transcription of epigenetically suppressed transposons and, noticeably, this activation is only transient. Therefore, it is likely that mechanisms countering the mitotic and meiotic inheritance of stress-triggered chromatin changes must exist but are undefined. To reveal these mechanisms, we screened for Arabidopsis mutants impaired in the resetting of stress-induced loss of epigenetic silencing and found that two chromatin regulators, Decrease in DNA methylation1 (DDM1) and Morpheus' Molecule1 (MOM1), act redundantly to restore prestress state and thus erase "epigenetic stress memory". In ddm1 mutants, stress hyperactivates heterochromatic transcription and transcription persists longer than in the wild type. However, this newly acquired state is not transmitted to the progeny. Strikingly, although stress-induced transcription in mom1 mutants is as rapidly silenced as in wild type, in ddm1 mom1 double mutants, transcriptional signatures of stress are able to persist and are found in the progeny of plants stressed as small seedlings. Our results reveal an important, previously unidentified function of DDM1 and MOM1 in rapid resetting of stress induced epigenetic states, and therefore also in preventing their mitotic propagation and transgenerational inheritance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.