ArticleJournal of natural products2014
Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.
Article in Journal of natural products, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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Who cites it
64 citing papers in PubMed, 148 citations in OpenAlex.
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- Antibacterial Activity of Guttation Droplets fromJournal of fungi (Basel, Switzerland) · 2026Article
- Hijacking the signal: a critical evaluation of quorum sensing inhibitors as a next-generation approach against Staphylococcus aureus.Cell communication and signaling : CCS · 2026Review
- Investigating the potential antibacterial, anti-biofilm, wound healing and anti-inflammatory activity of the extract of Aspergillus niger endophyte isolated from cucumber leaves: in vitro and in vivo study.BMC microbiology · 2025Article
- Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.Marine drugs · 2025Article
- Toward an Efficient Differentiation of TwoCurrent issues in molecular biology · 2025Article
- Quorum-sensingeLife · 2024Article
- Quorum-sensingbioRxiv : the preprint server for biology · 2024Article
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Unveiling Microbial Chemical Interactions Based on Metabolomics Approaches.Advances in experimental medicine and biology · 2023Article
- Chemodiversity and Anti-Leukemia Effect of Metabolites fromMetabolites · 2022Article
- Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review.RSC advances · 2022Review
- Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144).Phytochemistry · 2022Article
- Diverse host-associated fungal systems as a dynamic source of novel bioactive anthraquinones in drug discovery: Current status and future perspectives.Journal of advanced research · 2022Review
- Anti-neuroinflammatory effect of oxaline, isorhodoptilometrin, and 5-hydroxy-7-(2'-hydroxypropyl)-2-methyl-chromone obtained from the marine fungal strain Penicillium oxalicum CLC-MF05.Archives of pharmacal research · 2022Article
- Quorum Sensing Inhibition and Metabolic Intervention of 4-Hydroxycinnamic Acid AgainstFrontiers in microbiology · 2022Article
- Characterization ofMicroorganisms · 2021Article
- Fungal Guttation, a Source of Bioactive Compounds, and Its Ecological Role-A Review.Biomolecules · 2021Review
- Polyphasic Approach Utilized for the Identification of Two New Toxigenic Members ofJournal of fungi (Basel, Switzerland) · 2021Article
- 1-(4-Amino-2-hydroxyphenyl)ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa.Applied microbiology and biotechnology · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The endophytic fungus Penicillium restrictum was isolated from the stems of a milk thistle (Silybum marianum) plant. In culture, the fungus produced distinct red guttates, which have been virtually uninvestigated, particularly from the standpoint of chemistry. Hence, this study examined the chemical mycology of P. restrictum and, in doing so, uncovered a series of both known and new polyhydroxyanthraquinones (1-9). These compounds were quorum sensing inhibitors in a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA), with IC50 values ranging from 8 to 120 μM, suggesting antivirulence potential for the compounds. Moreover, the spatial and temporal distribution of the polyhydroxyanthraquinones was examined in situ via desorption electrospray ionization-mass spectrometry (DESI-MS) imaging, demonstrating the first application of this technique to a guttate-forming fungus and revealing both the concentration of secondary metabolites at the ventral surface of the fungus and their variance in colonies of differing ages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.