ArticleFEMS yeast research2014
Secretion and filamentation are mediated by the Candida albicans t-SNAREs Sso2p and Sec9p.
Article in FEMS yeast research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Endocytosis Mediated byMicroorganisms · 2026Article
- Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans.Genetics · 2025Article
- The development of extracellular vesicle markers for the fungal phytopathogen Colletotrichum higginsianum.Journal of extracellular vesicles · 2022Article
- Candida albicansmSphere · 2021Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Protein markers forJournal of extracellular vesicles · 2020Article
- Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The exocyst in Candida albicans polarized secretion and filamentation.Current genetics · 2016Review
- Functional Analysis of the Exocyst Subunit Sec15 in Candida albicans.Eukaryotic cell · 2015Article
- The Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and Is a Determinant of Hyphal Branching.Eukaryotic cell · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To study the role of late secretion in Candida albicans pathogenesis, we created conditional mutant C. albicans strains in which the t-SNARE-encoding genes SSO2 or SEC9 were placed under the control of a tetracycline-regulated promoter. In repressing conditions, C. albicans tetR-SSO2 and tetR-SEC9 mutant strains were defective in cytokinesis and secretion of aspartyl proteases and lipases. The mutant strains also exhibited a defect in filamentation compared with controls, and thus, we followed the fate of the C. albicans Spitzenkörper, an assembly of secretory vesicles thought to act as a vesicle supply center for the growing hyphae. In the absence of Ca Sso2p, the Spitzenkörper dissipated within 5 h and thin-section electron microscopy revealed an accumulation of secretory vesicles. Moreover, the hyphal tip developed into a globular yeast-like structure rather than maintaining a typical narrow hyphae. These studies indicate that late secretory t-SNARE proteins in C. albicans are required for fundamental cellular processes and contribute to virulence-related attributes of C. albicans pathogenesis. Moreover, these results provide direct evidence for a key role of SNARE proteins in vesicle-mediated polarized hyphal growth of C. albicans.
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