Evidence map›Paper›PMID 24911583›Full record

ReviewJournal of molecular biology2014

The yin and yang of bacterial resilience in the human gut microbiota.

Molly K Gibson, Mitchell W Pesesky, Gautam Dantas

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
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  16. Review
  17. Factors Obscuring the Role ofInternational journal of environmental research and public health · 2020
    Review
  18. Article
  19. Necrotizing enterocolitis: It's not all in the gut.Experimental biology and medicine (Maywood, N.J.) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Molly K GibsonCenter for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mitchell W PeseskyCenter for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gautam DantasCenter for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. Electronic address: dantas@wustl.edu.

Funding

METAGENOMIC ENGINEERING OF PROBIOTIC BACTERIA TO IMPROVE INTESTINAL COLONIZATIONDP2DK098089 · NIDDK · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM · 2012 to 2012
$2.1M
ESTABLISHMENT AND DYNAMICS OF ANTIBIOTIC RESISTANCE RESERVOIRS IN DEVELOPING INTER01GM099538 · NIGMS · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM · 2013 to 2016
$1.2M
NIDDK NIH HHS DP2 DK098089NIDDK NIH HHS DP2DK098089NIGMS NIH HHS R01 GM099538NIGMS NIH HHS R01GM099538
6 · The paper itself

Abstract

The human gut is home to trillions of microbes that form a symbiotic relationship with the human host. During health, the intestinal microbiota provides many benefits to the host and is generally resistant to colonization by new species; however, disruption of this complex community can lead to pathogen invasion, inflammation, and disease. Restoration and maintenance of a healthy gut microbiota composition requires effective therapies to reduce and prevent colonization of harmful bacteria (pathogens) while simultaneously promoting growth of beneficial bacteria (probiotics). Here we review the mechanisms by which the host modulates the gut community composition during health and disease, and we discuss prospects for antibiotic and probiotic therapy for restoration of a healthy intestinal community following disruption.

Indexed as

Host-Pathogen InteractionsMicrobiotaSymbiosisGastrointestinal TractHumansantibiotic resistancebacterial resiliencegenetic engineeringhuman gut microbiotaprobiotics

Identifiers

PMID24911583
PMCPMC4252752

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.