ArticleJournal of insect physiology2014
Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria.
Article in Journal of insect physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A Systematic Review of the Effects of Temperature onInternational journal of environmental research and public health · 2021Pooled it
- Fluctuating Warm and Humid Conditions Differentially Impact Immunity and Development in the Malaria Vector Anopheles stephensi.Global change biology · 2025Article
- Thermal adaptation inProceedings. Biological sciences · 2025Article
- Thermal variation influences the transcriptome of the major malaria vector Anopheles stephensi.Communications biology · 2025Article
- Article
- Extreme heat reduces host and parasite performance in a butterfly-parasite interaction.Proceedings. Biological sciences · 2024Article
- Blood meals from 'dead-end' vertebrate hosts enhance transmission potential of malaria-infected mosquitoes.One health (Amsterdam, Netherlands) · 2023Article
- Humidity - The overlooked variable in the thermal biology of mosquito-borne disease.Ecology letters · 2023Article
- Partitioning variance in immune traits in a zooplankton host-Fungal parasite system.Ecology and evolution · 2022Article
- The neglected role of relative humidity in the interannual variability of urban malaria in Indian cities.Nature communications · 2022Article
- Thermal biology of mosquito-borne disease.Ecology letters · 2019Review
- Malaria surveillance from both ends: concurrent detection of Plasmodium falciparum in saliva and excreta harvested from Anopheles mosquitoes.Parasites & vectors · 2019Article
- Managing mosquitoes and ticks in a rapidly changing world - Facts and trends.Saudi journal of biological sciences · 2019Review
- Regional variation in life history traits and plastic responses to temperature of the major malaria vector Nyssorhynchus darlingi in Brazil.Scientific reports · 2019Article
- Field Relevant Variation in Ambient Temperature Modifies Density-Dependent Establishment ofFrontiers in microbiology · 2019Article
- Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection.PLoS pathogens · 2018Article
- Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control.Evolutionary applications · 2018Article
- Responses to a warming world: Integrating life history, immune investment, and pathogen resistance in a model insect species.Ecology and evolution · 2017Article
- Fine-scale variation in microclimate across an urban landscape shapes variation in mosquito population dynamics and the potential of Aedes albopictus to transmit arboviral disease.PLoS neglected tropical diseases · 2017Article
- Quantitative real-time PCR analysis ofPeerJ · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The extent to which environmental factors influence the ability of Anopheles mosquitoes to transmit malaria parasites remains poorly explored. Environmental variation, such as change in ambient temperature, will not necessarily influence the rates of host and parasite processes equivalently, potentially resulting in complex effects on infection outcomes. As proof of principle, we used Anopheles stephensi and the rodent malaria parasite, Plasmodium yoelii, to examine the effects of a range of constant temperatures on one aspect of host defense (detected as alterations in expression of nitric oxide synthase gene - NOS) to parasite infection. We experimentally boosted mosquito midgut immunity to infection through dietary supplementation with the essential amino acid l-Arginine (l-Arg), which increases midgut nitric oxide (NO) levels by infection-induced NOS catalysis in A. stephensi. At intermediate temperatures, supplementation reduced oocyst prevalence, oocyst intensity, and sporozoite prevalence suggesting that the outcome of parasite infection was potentially dependent upon the rate of NOS-mediated midgut immunity. At low and high temperature extremes, however, infection was severely constrained irrespective of supplementation. The effects of l-Arg appeared to be mediated by NO-dependent negative feedback on NOS expression, as evidenced by depressed NOS expression in l-Arg treated groups at temperatures where supplementation decreased parasite infection. These results suggest the need to consider the direct (e.g. effects of mosquito body temperature on parasite physiology) and indirect effects (e.g. mediated through changes in mosquito physiology/immunity) of environmental factors on mosquito-malaria interactions in order to understand natural variation in vector competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.