ArticlePloS one2014
Insulin-like growth factor-1 as a prognostic marker in patients with acute ischemic stroke.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Association between oxidative stress-related IGF-1 and prognosis after ischemic stroke: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia.Cell discovery · 2026Article
- Insulin-like growth factor 1 and its prognostic value in the course of acute ischemic cerebrovascular events.Archives of medical sciences. Atherosclerotic diseases · 2023Article
- Retraction: Plasma D-Dimer Predicts Short-Term Poor Outcome after Acute Ischemic Stroke.PloS one · 2022Article
- Retraction: Plasma D-Dimer Levels Are Associated with Stroke Subtypes and Infarction Volume in Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Retraction: Cortisol as a Prognostic Marker of Short-Term Outcome in Chinese Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke.Frontiers in physiology · 2022Article
- Retraction: The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk.PloS one · 2022Article
- Retraction: Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke.PloS one · 2022Article
- Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2021Article
- Insulin-Like Growth Factor-1 Differentially Modulates Glutamate-Induced Toxicity and Stress in Cells of the Neurogliovascular Unit.Frontiers in aging neuroscience · 2021Article
- Amelioration of cognitive impairment following growth hormone replacement therapy: A case report and review of literature.World journal of clinical cases · 2020Article
- Sex differences in Alzheimer's disease: Understanding the molecular impact.Brain research · 2019Review
- 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain.Journal of molecular endocrinology · 2018Review
- Neurotrophic and Neuroregenerative Effects of GH/IGF1.International journal of molecular sciences · 2017Review
- Sex differences in stroke therapies.Journal of neuroscience research · 2017Review
- Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Article
- Central IGF-I Receptors in the Brain are Instrumental to Neuroprotection by Systemically Injected IGF-I in a Rat Model for Ischemic Stroke.CNS neuroscience & therapeutics · 2016Article
Corrections and comments
- Retraction · 2022-03-30Author Unresponsive · Concerns/Issues about Data · Duplication of/in Article · Paper Mill ·
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInsulin-like growth factor-1 (IGF-1) has been associated with cardiovascular risk factors and atherosclerosis. The aim of the present study was to evaluate the prognostic value of IGF-1 levels in patients with acute ischemic stroke (AIS).
methodsAll patients with first-ever AIS from August 1, 2012 to August 31, 2013 were recruited to participate in the study. Clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to serum IGF-1 levels. For the assessment of functional outcome at 90 days Modified Rankin Scale (mRS) was used. On admission, serum IGF-1 levels were determined by chemiluminescence immunoassay. The influence of IGF-1 levels on functional outcome and death was assessed by multivariate logistic regression analysis.
resultsPatients with an unfavorable outcomes and non-survivors had significantly decreased serum IGF-1 levels on admission (P<0.0001 for both). IGF-1 was an independent prognostic marker of functional outcome and death [odds ratio 0.89 (0.84-0.93) and 0.90 (0.84-0.95), respectively, P<0.0001 for both, adjusted for age, NIHSS score and other predictors] in patients with ischemic stroke. Serum IGF-1 levels ≤130 ng/mL was as an value indicator for unfavorable functional outcome (OR 3.31, 95% CI:1.87-5.62; P<0.0001), after adjusting for other significant confounders.
conclusionsWe reported a significant association between low serum IGF-1 levels and unfavorable functional outcome and death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.