Evidence map›Paper›PMID 24911157›Full record

ArticlePloS one2014

Influencing factors of new-onset diabetes after a renal transplant and their effects on complications and survival rate.

Chaoyang Lv, Minling Chen, Ming Xu, Guiping Xu, Yao Zhang, Shunmei He, Mengjuan Xue, Jian Gao, Mingxiang Yu, Xin Gao and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489043 (Exercise, Prediabetes and Diabetes After Renal Transplantation.), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489043 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Exercise, Prediabetes and Diabetes After Renal Transplantation.

TypeinterventionalSponsorHospital Universitario de CanariasRan2019 to 2021Enrolled60ConditionsDiabetes MellitusArmsExercise and healthy lifestyle recommendations
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Prognostic impact of post-transplant diabetes mellitus in kidney allograft recipients: a meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chaoyang LvDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Minling ChenDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China; Department of Endocrinology and Metabolism, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine (The People's Hospital of Fujian Province), Fuzhou, P.R. China.
Ming XuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai, P.R. China.
Guiping XuDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China; Department of Cadre's Ward, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian, P.R. China.
Yao ZhangDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Shunmei HeDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Mengjuan XueDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Jian GaoEvidence Base Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Mingxiang YuDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Xin GaoDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Tongyu ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo discuss the onset of and relevant risk factors for new-onset diabetes after a transplant (NODAT) in patients who survive more than 1 year after undergoing a renal transplant and the influence of these risk factors on complications and long-term survival.

methodA total of 428 patients who underwent a renal transplant between January 1993 and December 2008 and were not diabetic before surgery were studied. The prevalence rate of and relevant risk factors for postoperative NODAT were analyzed on the basis of fasting plasma glucose (FPG) levels, and differences in postoperative complications and survival rates between patients with and without NODAT were compared.

resultsThe patients in this study were followed up for a mean of 5.65 ± 3.68 years. In total, 87 patients (20.3%) developed NODAT. Patients who converted from treatment with CSA to FK506 had increased prevalence rates of NODAT (P <0.05). Multi-factor analysis indicated that preoperative FPG level (odds ratio [OR]  =  1.48), age (OR  =  1.10), body mass index (OR  =  1.05), hepatitis C virus infection (OR  =  2.72), and cadaveric donor kidney (OR  =  1.18) were independent risk factors for NODAT (All P <0.05). Compared with the N-NODAT group, the NODAT group had higher prevalence rates (P < 0.05) of postoperative infection, hypertension, and dyslipidemia; in addition, the survival rate and survival time of the 2 groups did not significantly differ.

conclusionAmong the patients who survived more than 1 year after a renal transplant, the prevalence rate of NODAT was 20.32%. Preoperative FPG level, age, body mass index, hepatitis C virus infection, and cadaveric donor kidney were independent risk factors for NODAT. Patients who converted from treatment with CSA to FK506 after a renal transplant had aggravated impairments in glycometabolism. Patients with NODAT were also more vulnerable to postoperative complications such as infection, hypertension, and hyperlipidemia.

Indexed as

AdultBlood GlucoseCause of DeathDiabetes MellitusFastingFemaleHumansImmunosuppressive AgentsKidney TransplantationMaleMiddle AgedPatient Outcome AssessmentPrevalenceRetrospective StudiesRisk FactorsSurvival RateBlood GlucoseImmunosuppressive Agents

Identifiers

PMID24911157
PMCPMC4050028

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Registered trials

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