SynthesisPloS one2014
Motor phenotype of decline in cognitive performance among community-dwellers without dementia: population-based study and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Effects of Pure Cognitive Training on Gait and Balance in Older Adults: Systematic Review and Meta-Analysis.JMIR aging · 2026Pooled it
- Effects of tai chi on postural balance and quality of life among the elderly with gait disorders: A systematic review.PloS one · 2023Pooled it
- Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.Journal of the American Medical Directors Association · 2016Pooled it
- Sensor-based balance training with motion feedback in people with mild cognitive impairment.Journal of rehabilitation research and development · 2016Trial
- The relationship between motoric cognitive risk syndrome and all-cause mortality in older people: findings from CHARLS 2011-2023.Archives of public health = Archives belges de sante publique · 2025Article
- Differential dementia risks of motoric cognitive risk syndrome and mild cognitive impairment among older adults in China: a 7-year cohort study.BMC geriatrics · 2025Article
- Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment.CNS neuroscience & therapeutics · 2025Article
- Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Age and beta amyloid deposition impact gait speed, stride length, and gait smoothness while transitioning from an even to an uneven walking surface in older adults.Human movement science · 2024Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- Machine learning approach to classifying declines of physical function and muscle strength associated with cognitive function in older women: gait characteristics based on three speeds.Frontiers in public health · 2024Article
- Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment.Journal of clinical medicine · 2023Article
- Minding your steps: a cross-sectional pilot study using foot-worn inertial sensors and dual-task gait analysis to assess the cognitive status of older adults with mobility limitations.BMC geriatrics · 2023Article
- Influencing factors on instrumental activities of daily living functioning in people with mild cognitive disorder - a secondary investigation of cross-sectional data.BMC geriatrics · 2022Article
- Associations between gait speed and brain structure in amnestic mild cognitive impairment: a quantitative neuroimaging study.Brain imaging and behavior · 2022Article
- Dividing attention during the Timed Up and Go enhances associations of several subtask performances with MCI and cognition.PloS one · 2022Article
- High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease.Frontiers in neuroscience · 2022Article
- Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer's Disease: Studies in the 3xTg-AD Mice.Biomedicines · 2021Article
- Combining Multimodal Behavioral Data of Gait, Speech, and Drawing for Classification of Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2021Article
- Gait Kinematic and Kinetic Characteristics of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Decline: A Cross-Sectional Study.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundDecline in cognitive performance is associated with gait deterioration. Our objectives were: 1) to determine, from an original study in older community-dwellers without diagnosis of dementia, which gait parameters, among slower gait speed, higher stride time variability (STV) and Timed Up & Go test (TUG) delta time, were most strongly associated with lower performance in two cognitive domains (i.e., episodic memory and executive function); and 2) to quantitatively synthesize, with a systematic review and meta-analysis, the association between gait performance and cognitive decline (i.e., mild cognitive impairment (MCI) and dementia).
methodsBased on a cross-sectional design, 934 older community-dwellers without dementia (mean±standard deviation, 70.3±4.9years; 52.1% female) were recruited. A score at 5 on the Short Mini-Mental State Examination defined low episodic memory performance. Low executive performance was defined by clock-drawing test errors. STV and gait speed were measured using GAITRite system. TUG delta time was calculated as the difference between the times needed to perform and to imagine the TUG. Then, a systematic Medline search was conducted in November 2013 using the Medical Subject Heading terms "Delirium," "Dementia," "Amnestic," "Cognitive disorders" combined with "Gait" OR "Gait disorders, Neurologic" and "Variability."
findingsA total of 294 (31.5%) participants presented decline in cognitive performance. Higher STV, higher TUG delta time, and slower gait speed were associated with decline in episodic memory and executive performances (all P-values <0.001). The highest magnitude of association was found for higher STV (effect size = -0.74 [95% Confidence Interval (CI): -1.05;-0.43], among participants combining of decline in episodic memory and in executive performances). Meta-analysis underscored that higher STV represented a gait biomarker in patients with MCI (effect size = 0.48 [95% CI: 0.30;0.65]) and dementia (effect size = 1.06 [95% CI: 0.40;1.72]).
conclusionHigher STV appears to be a motor phenotype of cognitive decline.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.