ArticleOmics : a journal of integrative biology2014
Medium-term variability of the human serum metabolome in the Atherosclerosis Risk in Communities (ARIC) study.
Article in Omics : a journal of integrative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Residential green space, air pollution, and related metabolites in association with depression among cancer survivors.Nature communications · 2026Article
- Reproducibility of Plasma Metabolome over 1 Year in a Population-Based Cohort of Black Breast Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Dietary biomarkers-an update on their validity and applicability in epidemiological studies.Nutrition reviews · 2024Review
- Untargeted metabolomics reveals the effects of pre-analytic storage on serum metabolite profiles from healthy cats.PloS one · 2024Article
- Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study.Environmental science & technology · 2023Article
- Associations of sodium and potassium consumption with the gut microbiota and host metabolites in a population-based study in Chinese adults.The American journal of clinical nutrition · 2020Article
- Potential for Novel Biomarkers in Diabetes-Associated Chronic Kidney Disease: Epigenome, Metabolome, and Gut Microbiome.Biomedicines · 2020Review
- Metabolomics Research in Chronic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2018 · on this mapArticle
- Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study.Translational psychiatry · 2017Article
- Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis.Genetic epidemiology · 2016Article
- Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.Omics : a journal of integrative biology · 2016Article
- Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Metabolomics is a systems biology tool providing small molecule signatures of disease etiology. In order to estimate the biologic variability of the human serum metabolome, this study calculated intraclass correlation coefficients (ICCs) for 178 stably-detected metabolites measured by untargeted chromatography/mass spectrometry. We studied a subsample of 60 participants (57% males, 70% Caucasians, aged 73.77±5.3 years) in the Atherosclerosis Risk in Communities (ARIC) Study who provided two fasting serum samples 4-6 weeks apart. The median ICC across all metabolites was 0.60, and 82% of metabolites had at least fair variability (i.e., ICC>= 0.40). There was variation in the medium-term variability among metabolites, with those in the pathways of amino acid and lipid metabolism showing relatively high ICCs, and those in the carbohydrate pathway showing relatively low ICCs. The results of this study provide a valuable resource for future study design and outcome interpretation of mass spectrometry-based metabolomic studies in epidemiology.
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