Evidence map›Paper›PMID 24910719›Full record

ArticleCellular and molecular bioengineering2014

Hydraulic Pressure during Fluid Flow Regulates Purinergic Signaling and Cytoskeleton Organization of Osteoblasts.

Joseph D Gardinier, Vimal Gangadharan, Liyun Wang, Randall L Duncan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular bioengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. [Research advances of fluid bio-mechanics in bone].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017
    Review
  6. P2YCellular and molecular life sciences : CMLS · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph D GardinierBiomechanics and Movement Science, University of Delaware, Newark, DE, 19716 ; Department of Biological and Materials Science, University of Michigan, Ann Arbor, MI 48109.
Vimal GangadharanBiological Sciences, University of Delaware, Newark, DE, 19716.
Liyun WangBiomechanics and Movement Science, University of Delaware, Newark, DE, 19716 ; Department of Mechanical Engineering, University of Delaware, Newark, DE, 19716.
Randall L DuncanBiomechanics and Movement Science, University of Delaware, Newark, DE, 19716 ; Department of Mechanical Engineering, University of Delaware, Newark, DE, 19716 ; Biological Sciences, University of Delaware, Newark, DE, 19716.
University of Delaware · US

Funding

Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
Supplement to R01 Titled: Mechanosensing in the Bone Lacunar-Canalicular SystemR01AR054385 · NIAMS · UNIVERSITY OF DELAWARE · PI FARACH-CARSON, MARY C, WANG, LIYUN · 2007 to 2019
$3.8M
Mechanotransduction: Puringergic Signaling in BoneR01AR051901 · NIAMS · UNIVERSITY OF DELAWARE · PI DUNCAN, RANDALL L · 2005 to 2009
$1.6M
STRETCH CHANNEL FUNCTION IN THE UNLOADED OSTEOBLASTR01AR043222 · NIAMS · UNIVERSITY OF DELAWARE · PI DUNCAN, RANDALL L · 1996 to 2006
$1.2M
The Influence of PTH during Exercise on Bone QualityF32AR064668 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARDINIER, JOSEPH DANIEL · 2013 to 2014
$61k
NIAMS NIH HHS F32 AR064668NIAMS NIH HHS R01 AR043222NIAMS NIH HHS R01 AR051901NIAMS NIH HHS R01 AR054385NIGMS NIH HHS P30 GM103333
6 · The paper itself

Abstract

During physiological activities, osteoblasts experience a variety of mechanical forces that stimulate anabolic responses at the cellular level necessary for the formation of new bone. Previous studies have primarily investigated the osteoblastic response to individual forms of mechanical stimuli. However in this study, we evaluated the response of osteoblasts to two simultaneous, but independently controlled stimuli; fluid flow-induced shear stress (FSS) and static or cyclic hydrostatic pressure (SHP or CHP, respectively). MC3T3-E1 osteoblasts-like cells were subjected to 12dyn/cm

Indexed as

Actin cytoskeletonATP releaseFluid flowHydraulic pressureMechanotransductionNuclear factor-kappa BOsteoblasts

Identifiers

PMID24910719
PMCPMC4043371
OpenAlexW2011331601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.