ArticleFrontiers in genetics2014
Transposable elements in cancer as a by-product of stress-induced evolvability.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Therapeutic Stress-Induced Remodeling of Transposable Elements and TE-Gene Chimeras in KYSE150 Esophageal Squamous Cell Carcinoma Cells.International journal of molecular sciences · 2026Article
- Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen.Nature communications · 2025Article
- Review
- The role of transposable elements in aging and cancer.Biogerontology · 2023Review
- Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells.Cell discovery · 2023Article
- Review
- Telomeric DNA sequences in beetle taxa vary with species richness.Scientific reports · 2021Article
- Review
- Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer.Molecular cancer research : MCR · 2020Review
- Roles of Transposable Elements in the Different Layers of Gene Expression Regulation.International journal of molecular sciences · 2019Review
- Small non-coding RNAs as regulators of structural evolution and carcinogenesis.Non-coding RNA research · 2017Review
- Regulatory activities of transposable elements: from conflicts to benefits.Nature reviews. Genetics · 2017Review
- Potential movement of transposable elements through DNA circularization.Current genetics · 2016Review
- Putative RNA-directed adaptive mutations in cancer evolution.Transcription · 2016Article
- Accumulation of transposable elements in Hox gene clusters during adaptive radiation of Anolis lizards.Proceedings. Biological sciences · 2016Article
- Restricting retrotransposons: a review.Mobile DNA · 2016Review
- Formation of Extrachromosomal Circular DNA from Long Terminal Repeats of Retrotransposons in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2015Article
- Detecting endogenous retrovirus-driven tissue-specific gene transcription.Genome biology and evolution · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.