ReviewFrontiers in human neuroscience2014
Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients.
Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of Complete Spinal Cord Transection in Neonatal and Juvenile Rats on Parvalbumin-Positive Inputs and Perineuronal Net Formation on Chx10-Positive V2a Interneurons.Developmental neuroscience · 2026Article
- Lessons Learned and Recommendations from a SCOPE Spinal Cord Injury Neurorestorative Clinical Trials Update.Neurotrauma reports · 2025Review
- Article
- Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles.Brain sciences · 2021Article
- Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series.Animals : an open access journal from MDPI · 2021Article
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Computational Modeling of Spinal Locomotor Circuitry in the Age of Molecular Genetics.International journal of molecular sciences · 2021Review
- TheJournal of functional morphology and kinesiology · 2020Article
- Spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2020Review
- Article
- The Relationship between Trans-Lesional Conduction, Motor Neuron Pool Excitability, and Motor Function in Dogs with Incomplete Recovery from Severe Spinal Cord Injury.Journal of neurotrauma · 2017Article
- What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury.Journal of neurotrauma · 2017Review
- The Brain Dead Patient Is Still Sentient: A Further Reply to Patrick Lee and Germain Grisez.The Journal of medicine and philosophy · 2016Article
- Spinal Cord Stimulation and Augmentative Control Strategies for Leg Movement after Spinal Paralysis in Humans.CNS neuroscience & therapeutics · 2016Review
- A leech model for homeostatic plasticity and motor network recovery after loss of descending inputs.Journal of neurophysiology · 2016Article
- Compensatory plasticity restores locomotion after chronic removal of descending projections.Journal of neurophysiology · 2015Article
- Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions.Frontiers in systems neuroscience · 2015Review
- Editorial: Neuro-motor control and feed-forward models of locomotion in humans.Frontiers in human neuroscience · 2015Article
- Human locomotion under reduced gravity conditions: biomechanical and neurophysiological considerations.BioMed research international · 2014Review
- EMG patterns during assisted walking in the exoskeleton.Frontiers in human neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ambulation or walking is one of the main gaits of locomotion. In terrestrial animals, it may be defined as a series of rhythmic and bilaterally coordinated movement of the limbs which creates a forward movement of the body. This applies regardless of the number of limbs-from arthropods with six or more limbs to bipedal primates. These fundamental similarities among species may explain why comparable neural systems and cellular properties have been found, thus far, to control in similar ways locomotor rhythm generation in most animal models. The aim of this article is to provide a comprehensive review of the known structural and functional features associated with central nervous system (CNS) networks that are involved in the control of ambulation and other stereotyped motor patterns-specifically Central Pattern Generators (CPGs) that produce basic rhythmic patterned outputs for locomotion, micturition, ejaculation, and defecation. Although there is compelling evidence of their existence in humans, CPGs have been most studied in reduced models including in vitro isolated preparations, genetically-engineered mice and spinal cord-transected animals. Compared with other structures of the CNS, the spinal cord is generally considered as being well-preserved phylogenetically. As such, most animal models of spinal cord-injured (SCI) should be considered as valuable tools for the development of novel pharmacological strategies aimed at modulating spinal activity and restoring corresponding functions in chronic SCI patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.