ReviewFrontiers in behavioral neuroscience2014
The role of dopamine in risk taking: a specific look at Parkinson's disease and gambling.
Review in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2024Guideline
- Weighing Open Science Against Research Participation Burden in Informed Consent: A Randomized Pilot Study.Journal of empirical research on human research ethics : JERHRE · 2025Trial
- Dopamine Receptor-Specific Contributions to the Computation of Value.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025Article
- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
- Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine.bioRxiv : the preprint server for biology · 2024Article
- Dorsolateral prefrontal cortex plays causal role in probability weighting during risky choice.Scientific reports · 2022Article
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies.Frontiers in psychiatry · 2021Review
- Article
- Dopamine-Dependent Loss Aversion during Effort-Based Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Positive reward prediction errors during decision-making strengthen memory encoding.Nature human behaviour · 2019Article
- Article
- The role of 'jackpot' stimuli in maladaptive decision-making: dissociable effects of D1/D2 receptor agonists and antagonists.Psychopharmacology · 2018Article
- Reward Prediction Errors in Drug Addiction and Parkinson's Disease: from Neurophysiology to Neuroimaging.Current neurology and neuroscience reports · 2017Review
- Chronic administration of the dopamine DPsychopharmacology · 2017Article
- Learning Reward Uncertainty in the Basal Ganglia.PLoS computational biology · 2016Article
- Orbitofrontal or accumbens dopamine depletion does not affect risk-based decision making in rats.Cognitive, affective & behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling is the major abnormality in Parkinson's disease. Dopamine agonists have been implicated in the occurrence of impulse control disorders in Parkinson's disease patients, the most common being pathological gambling, compulsive sexual behavior, and compulsive buying. Recently, a number of functional imaging studies investigating impulse control disorders in Parkinson's disease have been published. Here we review this literature, and attempt to place it within a decision-making framework in which potential gains and losses are evaluated to arrive at optimum choices. We also provide a hypothetical but still incomplete model on the effect of dopamine agonist treatment on these value and risk assessments. Two of the main brain structures thought to be involved in computing aspects of reward and loss are the ventral striatum (VStr) and the insula, both dopamine projection sites. Both structures are consistently implicated in functional brain imaging studies of pathological gambling in Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.