ArticleFrontiers in behavioral neuroscience2014
Pre-reproductive maternal enrichment influences offspring developmental trajectories: motor behavior and neurotrophin expression.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Environmental Enrichment Protects against Neurotoxic Effects of Lipopolysaccharide: A Comprehensive Overview.International journal of molecular sciences · 2023Review
- Environmental Enrichment Enhances Cerebellar Compensation and Develops Cerebellar Reserve.International journal of environmental research and public health · 2022Review
- Environmental influences on placental programming and offspring outcomes following maternal immune activation.Brain, behavior, and immunity · 2020Article
- Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms.Nature communications · 2019Article
- Prenatal and Early Postnatal Environmental Enrichment Reduce Acute Cell Death and Prevent Neurodevelopment and Memory Impairments in Rats Submitted to Neonatal Hypoxia Ischemia.Molecular neurobiology · 2018Article
- Cerebellar BDNF Promotes Exploration and Seeking for Novelty.The international journal of neuropsychopharmacology · 2018Article
- Maternal Protein Malnutrition: Current and Future Perspectives of Spirulina Supplementation in Neuroprotection.Frontiers in neuroscience · 2018Review
- Pre-reproductive Parental Enriching Experiences Influence Progeny's Developmental Trajectories.Frontiers in behavioral neuroscience · 2018Review
- Effect of Maternal Stress Prior to Conception on Hippocampal BDNF Signaling in Rat Offspring.Molecular neurobiology · 2017Article
- Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies.Neural plasticity · 2017Review
- Influence of Pre-reproductive Maternal Enrichment on Coping Response to Stress and Expression of c-Fos and Glucocorticoid Receptors in Adolescent Offspring.Frontiers in behavioral neuroscience · 2017Article
- Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis.Acta neuropathologica communications · 2016Article
- Environmental enrichment as an intervention for adverse health outcomes of prenatal stress.Environmental epigenetics · 2016Review
- Transgenerational effects of environmental enrichment on repetitive motor behavior development.Behavioural brain research · 2016Article
- Pre-reproductive maternal enrichment influences rat maternal care and offspring developmental trajectories: behavioral performances and neuroplasticity correlates.Frontiers in behavioral neuroscience · 2015Article
- Interaction does Count: A Cross-Fostering Study on Transgenerational Effects of Pre-reproductive Maternal Enrichment.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental enrichment is usually applied immediately after weaning or in adulthood, with strong effects on CNS anatomy and behavior. To examine the hypothesis that a pre-reproductive environmental enrichment of females could affect the motor development of their offspring, female rats were reared in an enriched environment from weaning to sexual maturity, while other female rats used as controls were reared under standard conditions. Following mating with standard-reared males, all females were housed individually. To evaluate the eventual transgenerational influence of positive pre-reproductive maternal experiences, postural and motor development of male pups was analyzed from birth to weaning. Moreover, expression of Brain Derived Neurotrophic Factor and Nerve Growth Factor in different brain regions was evaluated at birth and weaning. Pre-reproductive environmental enrichment of females affected the offspring motor development, as indicated by the earlier acquisition of complex motor abilities displayed by the pups of enriched females. The earlier acquisition of motor abilities was associated with enhanced neurotrophin levels in striatum and cerebellum. In conclusion, maternal positive experiences were transgenerationally transmitted, and influenced offspring phenotype at both behavioral and biochemical levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.