ArticleDose-response : a publication of International Hormesis Society2014
Nonlinear effects of nanoparticles: biological variability from hormetic doses, small particle sizes, and dynamic adaptive interactions.
Article in Dose-response : a publication of International Hormesis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
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- The Composition of the Dispersion Medium Determines the Antibacterial Properties of Copper (II) Oxide Nanoparticles AgainstNanomaterials (Basel, Switzerland) · 2025Article
- Article
- The Conditions Matter: The Toxicity of Titanium Trisulfide Nanoribbons to BacteriaInternational journal of molecular sciences · 2023Article
- Assessment of the Tolerance of a ChlorophyteNanomaterials (Basel, Switzerland) · 2023Article
- In Vitro Study to Evaluate the Efficacy of Ultrasonicated Ethanolic Extract of Rosmarinus officinalis and its Chitosan-Based Nanoparticles Against Eimeria tenella Oocysts of Chickens.AAPS PharmSciTech · 2022Article
- Low Dose and Non-Targeted Radiation Effects in Environmental Protection and Medicine-A New Model Focusing on Electromagnetic Signaling.International journal of molecular sciences · 2022Review
- Shape-Dependent Toxicity of Silver Nanoparticles on Freshwater Cnidarians.Nanomaterials (Basel, Switzerland) · 2022Article
- Article
- Antifungal Carvacrol Loaded Chitosan Nanoparticles.Antibiotics (Basel, Switzerland) · 2021Article
- Biostimulation and toxicity: The magnitude of the impact of nanomaterials in microorganisms and plants.Journal of advanced research · 2021Review
- Characterization and Biotechnological Potential of Intracellular Polyhydroxybutyrate byPolymers · 2021Article
- CdSe/ZnS Core-Shell-Type Quantum Dot Nanoparticles Disrupt the Cellular Homeostasis in Cellular Blood-Brain Barrier Models.International journal of molecular sciences · 2021Article
- The Challenges of 21st Century Neurotoxicology: The Case of Neurotoxicology Applied to Nanomaterials.Frontiers in toxicology · 2021Article
- Impact of Carbon Nanomaterials on the Antioxidant System of Tomato Seedlings.International journal of molecular sciences · 2019Article
- Inhibitory activity of chitosan nanoparticles against Cryptosporidium parvum oocysts.Parasitology research · 2019Article
- Multivariate modeling of engineered nanomaterial features associated with developmental toxicity.NanoImpact · 2019Article
- Nanoparticles and Nanomaterials as Plant Biostimulants.International journal of molecular sciences · 2019Review
- DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats.International journal of nanomedicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Researchers are increasingly focused on the nanoscale level of organization where biological processes take place in living systems. Nanoparticles (NPs, e.g., 1-100 nm diameter) are small forms of natural or manufactured source material whose properties differ markedly from those of the respective bulk forms of the "same" material. Certain NPs have diagnostic and therapeutic uses; some NPs exhibit low-dose toxicity; other NPs show ability to stimulate low-dose adaptive responses (hormesis). Beyond dose, size, shape, and surface charge variations of NPs evoke nonlinear responses in complex adaptive systems. NPs acquire unique size-dependent biological, chemical, thermal, optical, electromagnetic, and atom-like quantum properties. Nanoparticles exhibit high surface adsorptive capacity for other substances, enhanced bioavailability, and ability to cross otherwise impermeable cell membranes including the blood-brain barrier. With super-potent effects, nano-forms can evoke cellular stress responses or therapeutic effects not only at lower doses than their bulk forms, but also for longer periods of time. Interactions of initial effects and compensatory systemic responses can alter the impact of NPs over time. Taken together, the data suggest the need to downshift the dose-response curve of NPs from that for bulk forms in order to identify the necessarily decreased no-observed-adverse-effect-level and hormetic dose range for nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.