Evidence map›Paper›PMID 24910557›Full record

ReviewThe Yale journal of biology and medicine2014

The pathogenesis of obesity from a genomic and systems biology perspective.

Candace Levian, Esmeralda Ruiz, Xia Yang

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in The Yale journal of biology and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Journal of clinical medicine · 2018
    Article
  8. Article
  9. Weight maintenance: challenges, tools and strategies for primary care physicians.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016
    Review
  10. Article
  11. Article
  12. Article
  13. Biomarkers linking PCB exposure and obesity.Current pharmaceutical biotechnology · 2014
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Candace LevianDepartment of Integrative Biology and Physiology, University of California, Los Angeles.
Esmeralda RuizDepartment of Integrative Biology and Physiology, University of California, Los Angeles.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124
6 · The paper itself

Abstract

The recent obesity epidemic has imposed significant health, economical, and societal concerns. However, effective preventive and therapeutic strategies are currently lacking, primarily due to a lack of comprehensive understanding of the underlying molecular mechanisms. Recent genome-wide scans of genetic variants, transcriptome, and epigenome have uncovered >50 genetic loci that predispose individuals to obesity and revealed hundreds of genes with altered transcriptional activity and/or epigenetic variations in obesity-related tissues upon various environmental challenges such as high caloric diets, lack of physical activity, and environmental chemicals. These discoveries highlight the importance of genes involved in the control of energy homeostasis and food intake by the central nervous system, as well as genes contributing to lipid metabolism, adipogenesis, fat cell differentiation, and immune response in peripheral tissues, in obesity development. Future studies that are directed to obtain a more comprehensive, systems-level understanding of disease mechanisms and that test novel therapeutic strategies aiming at systems-level normalization of the obesity-related molecular alterations are warranted.

Indexed as

GenomicsSystems BiologyEnvironmentGenetic Predisposition to DiseaseHumansObesityRisk Factorsenvironmental risksepigenomeexercisegenetic risksgenomicshigh caloric dietsintegrative genomicsobesityobesogensystems biologytranscriptome

Identifiers

PMID24910557
PMCPMC4031785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.