Evidence map›Paper›PMID 24910427›Full record

ArticleCell reports2014

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

Penelope J Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacson

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03128450 phase2 / phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

A Single Arm, Open-Label，Pilot Study to Evaluate the Safety and Efficacy of Human Neural Stem Cells Injection (ANGE-S003) Through Nasal Way Delivery to Patients With Parkinson's Disease

TypeinterventionalSponsorSecond Affiliated Hospital of Soochow UniversityRan2017 to 2018Enrolled12ConditionsParkinson DiseaseArmshuman neural stem cell
NCT06422208 phase1enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

A Phase 1 Clinical Trial of Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease

TypeinterventionalSponsorPenelope J. Hallett, Ph.D.Ran2024 to 2027Enrolled6ConditionsParkinson DiseaseArmsAutologous midbrain dopamine neurons
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Penelope J HallettNeuroregeneration Research Institute, Harvard University and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Oliver CooperNeuroregeneration Research Institute, Harvard University and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Damaso SadiDivision of Neurosurgery, Department of Anatomy and Neurobiology, and Department of Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS B3H 3A7, Canada.
Harold RobertsonDivision of Neurosurgery, Department of Anatomy and Neurobiology, and Department of Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS B3H 3A7, Canada.
Ivar MendezDivision of Neurosurgery, Department of Anatomy and Neurobiology, and Department of Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS B3H 3A7, Canada.
Ole IsacsonNeuroregeneration Research Institute, Harvard University and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. Electronic address: isacson@hms.harvard.edu.
Dalhousie University · CAHarvard University · USMcLean Hospital · USQueen Elizabeth II Health Sciences Centre · CA

Funding

Transplantation of ES Cell-derived DA Neurons into PD Primate ModelsP50NS039793 · NINDS · MC LEAN HOSPITAL (BELMONT, MA) · PI ISACSON, OLE · 1999 to 2010
$16.3M
CIHRNINDS NIH HHS NS39793NINDS NIH HHS P50 NS039793
6 · The paper itself

Abstract

To determine the long-term health and function of transplanted dopamine neurons in Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and mitochondrial morphology were examined in human fetal midbrain cellular transplants. DAT was robustly expressed in transplanted dopamine neuron terminals in the reinnervated host putamen and caudate for at least 14 years after transplantation. The transplanted dopamine neurons showed a healthy and nonatrophied morphology at all time points. Labeling of the mitochondrial outer membrane protein Tom20 and α-synuclein showed a typical cellular pathology in the patients' own substantia nigra, which was not observed in transplanted dopamine neurons. These results show that the vast majority of transplanted neurons remain healthy for the long term in PD patients, consistent with clinical findings that fetal dopamine neuron transplants maintain function for up to 15-18 years in patients. These findings are critically important for the rational development of stem-cell-based dopamine neuronal replacement therapies for PD.

Indexed as

Dopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsHumansParkinson DiseaseDopamine Plasma Membrane Transport Proteins

Identifiers

PMID24910427
PMCPMC4105701
OpenAlexW2130749065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.