Evidence map›Paper›PMID 24910380›Full record

Trial reportBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2014

Exercise and stress management training prior to hematopoietic cell transplantation: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902.

Paul B Jacobsen, Jennifer Le-Rademacher, Heather Jim, Karen Syrjala, John R Wingard, Brent Logan, Juan Wu, Navneet S Majhail, William Wood, J Douglas Rizzo and 7 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01278927 (A Phase III Randomized, Multicenter Trial Testing Whether Exercise or Stress Management Improves Functional Status and Symptoms of Autologous and Allogeneic Recipients), which is not on this map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01278927 nacompletednot on this map

A Phase III Randomized, Multicenter Trial Testing Whether Exercise or Stress Management Improves Functional Status and Symptoms of Autologous and Allogeneic Recipients (BMT CTN #0902)

TypeinterventionalSponsorMedical College of WisconsinRan2011 to 2014Enrolled711ConditionsPhysiological StressArmsExercise, Stress Management, Exercise and Stress Management, Standard Care
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Trial
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  9. Lessons learned from a pilot randomized clinical trial of home-based exercise prescription before allogeneic hematopoietic cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
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  13. Pretransplantation Exercise and Hematopoietic Cell Transplantation Survival: A Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0902).Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Trial
  14. Trial
  15. Trajectories of Quality of Life after Hematopoietic Cell Transplantation: Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network 0902 Data.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016
    Trial
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  17. Review
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paul B JacobsenDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.
Jennifer Le-RademacherDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Heather JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.
Karen SyrjalaClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
John R WingardDivision of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida.
Brent LoganDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Juan WuThe EMMES Corporation, Washington, DC.
Navneet S MajhailBlood and Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio.
William WoodLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
J Douglas RizzoCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Nancy L GellerOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Carrie KitkoPediatric Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, Michigan.
Edward FaberDivision of Hematology/Oncology, University of Nebraska Medical Center, Omaha, Nebraska.
Muneer H AbidiDepartment of Medical Oncology, Wayne State University/Karmanos Cancer Institute, Detroit, Michigan.
Susan SlaterCenter for Hematologic Malignancies, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
Mary M HorowitzCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Stephanie J LeeClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: sjlee@fhcrc.org.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
Internet Studies to Enhance Long Term Survivorship after Hematologic MalignancyR01CA160684 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SYRJALA, KAREN LESLIE · 2011 to 2015
$3.4M
BLOOD AND MARROW TRANSPLANT CLINICAL RESEARCH NETWORKU01HL069246 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI APPELBAUM, FREDERICK · 2002 to 2010
$2.1M
Blood & Marrow Clinical Trials Network - Hutchinson Center Core Clinical SitU10HL069246 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI APPELBAUM, FREDERICK · 2011 to 2016
$1.1M
Blood and Marrow Transplant Clinical Trials Network (BMT CTN) - Core Clinical C*U10HL108987 · NHLBI · H. LEE MOFFITT CANCER CTR & RES INST · PI ANASETTI, CLAUDIO · 2011 to 2016
$1.0M
University of Michigan Core Clinical Center for BMT Research NetworkU10HL069330 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANIK, GREGORY A · 2011 to 2016
$959k
Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCTU10HL108945 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HESLOP, HELEN E · 2011 to 2016
$954k
The Ohio State Blood and Marrow Transplant Reseach ConsortiumU10HL109322 · NHLBI · OHIO STATE UNIVERSITY · PI DEVINE, STEVEN M. · 2011 to 2016
$947k
Sargrastim and Plerixafor vs. Filgrastim for Allogeneic Stem Cell MobilizationU10HL109137 · NHLBI · WASHINGTON UNIVERSITY · PI WESTERVELT, PETER · 2011 to 2016
$937k
Core Clinical Consortium for Blood and Marrow Transplant Clinical Trials NetworkU10HL069301 · NHLBI · UNIVERSITY OF FLORIDA · PI WINGARD, JOHN R. · 2011 to 2016
$882k
Translational Research in Blood and Marrow TranslplantationU10HL069310 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JONES, RICHARD J · 2011 to 2016
$777k
NCI NIH HHS R01 CA160684NCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069246NHLBI NIH HHS U10 HL069246NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U10HL069294NHLBI NIH HHS U10 HL069301NHLBI NIH HHS U10 HL069310NHLBI NIH HHS U10 HL069330NHLBI NIH HHS U10 HL108945NHLBI NIH HHS U10 HL108987NHLBI NIH HHS U10 HL109137NHLBI NIH HHS U10 HL109322NHLBI NIH HHS U10 HL109526
6 · The paper itself

Abstract

Studies show that engaging patients in exercise and/or stress management techniques during hematopoietic cell transplantation (HCT) improves quality of life. The Blood and Marrow Transplant Clinical Trials Network tested the efficacy of training patients to engage in self-directed exercise and stress management during HCT. The study randomized 711 patients at 21 centers to receive 1 of 4 training interventions before HCT: a self-directed exercise program, a self-administered stress management program, both, or neither. Participants completed self-reported assessments at enrollment and up to 180 days after HCT. Randomization was stratified by center and transplant type. There were no differences in the primary endpoints of the Physical Component Summary and Mental Component Summary scales of the Medical Outcomes Study Short Form 36 at day +100 among the groups, based on an intention-to-treat analysis. There also were no differences in overall survival, days of hospitalization through day +100 post-HCT, or in other patient-reported outcomes, including treatment-related distress, sleep quality, pain, and nausea. Patients randomized to training in stress management reported more use of those techniques, but patients randomized to training in exercise did not report more physical activity. Although other studies have reported efficacy of more intensive interventions, brief training in an easy-to-disseminate format for either self-directed exercise or stress management was not effective in our trial.

Indexed as

Exercise TherapyHematopoietic Stem Cell TransplantationTransplantation ConditioningAdolescentAdultAgedFemaleHematologic NeoplasmsHumansIntention to Treat AnalysisMaleMental Status ScheduleMiddle AgedMyeloablative AgonistsPrognosisQuality of LifeMyeloablative AgonistsAllogeneic hematopoietic cell transplantationAutologous hematopoietic cell transplantationExerciseQuality of lifeStress management

Identifiers

PMID24910380
PMCPMC4163109

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.