ArticleHippocampus2014
Age-associated changes in hippocampal-dependent cognition in Diversity Outbred mice.
Article in Hippocampus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice.Aging cell · 2025Article
- Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment.Molecular neurobiology · 2024Article
- Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Delayed formation of neural representations of space in aged mice.Aging cell · 2023Article
- Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction.PNAS nexus · 2023Article
- Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice.Neurobiology of stress · 2021Article
- Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons.Addiction biology · 2021Article
- Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus.Frontiers in aging neuroscience · 2021Article
- Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input.Neurobiology of aging · 2019Article
- Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.Neurobiology of aging · 2019Article
- Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions.Frontiers in aging neuroscience · 2019Article
- Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats.Neurobiology of aging · 2018Article
- Experience-Dependent Effects of Muscimol-Induced Hippocampal Excitation on Mnemonic Discrimination.Frontiers in systems neuroscience · 2018Article
- Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice.Frontiers in aging neuroscience · 2018Article
- Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus.Neuropharmacology · 2015Article
- Neurocognitive Aging and the Hippocampus across Species.Trends in neurosciences · 2015Review
- Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives.Experimental & molecular medicine · 2015Review
- Lifetime development of behavioural phenotype in the house mouse (Mus musculus).Frontiers in zoology · 2015Review
- Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Episodic memory impairment due to aging has been linked to hippocampal dysfunction. Evidence exists for alterations in specific circuits within the hippocampal system that are closely coupled to individual differences in the presence and severity of such memory loss. Here, we used the newly developed Diversity Outbred (DO) mouse that was designed to model the genetic diversity in human populations. Young and aged DO mice were tested in a hippocampal-dependent water maze task. Young mice showed higher proficiency and more robust memory compared to the overall performance of aged mice. A substantial number of the older mice, however, performed on par with the normative performance of the younger mice. Stereological quantification of somatostatin-immunoreactive neurons in the dentate hilus showed that high-performing young and unimpaired aged mice had similar numbers of somatostatin-positive interneurons, while aged mice that were impaired in the spatial task had significantly fewer such neurons. These data in the DO model tie loss of hilar inhibitory network integrity to age-related memory impairment, paralleling data in other rodent models.
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Registered trials
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