ArticleThe Journal of hand surgery2014
A comparative study of the effects of growth and differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model.
Article in The Journal of hand surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Facile and rapid fabrication of a novel 3D-printable, visible light-crosslinkable and bioactive polythiourethane for large-to-massive rotator cuff tendon repair.Bioactive materials · 2024Article
- Growth factors in the treatment of Achilles tendon injury.Frontiers in bioengineering and biotechnology · 2023Review
- 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells.Pharmaceutics · 2021Article
- The effect of fibrin formulation on cell migration in an in vitro tendon repair model.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2021Article
- A novel engineered purified exosome product patch for tendon healing: An explant in an ex vivo model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- In Vitro Innovation of Tendon Tissue Engineering Strategies.International journal of molecular sciences · 2020Review
- Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells.International journal of molecular sciences · 2020Article
- Evaluation of hollow mesh augmentation on the biomechanical properties of the flexor tendon repaired with modified Kessler technique.Journal of orthopaedic translation · 2020Article
- Lateral slit delivery of bone marrow stromal cells enhances regeneration in the decellularized allograft flexor tendon.Journal of orthopaedic translation · 2019Article
- A modified preplate technique for efficient isolation and proliferation of mice muscle-derived stem cells.Cytotechnology · 2018Article
- BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cellsExperimental and therapeutic medicine · 2018Article
- From skeletal muscle to stem cells: an innovative and minimally-invasive process for multiple species.Scientific reports · 2017Article
- Myostatin promotes tenogenic differentiation of C2C12 myoblast cells through Smad3.FEBS open bio · 2017Article
- The revitalisation of flexor tendon allografts with bone marrow stromal cells and mechanical stimulation: AnBone & joint research · 2017Article
- Effectiveness of Biologic Factors in Shoulder Disorders.The open orthopaedics journal · 2017Review
- Rotator cuff repair augmentation in a rat model that combines a multilayer xenograft tendon scaffold with bone marrow stromal cells.Journal of shoulder and elbow surgery · 2016Article
- Effect of Fibrin Formulation on Initial Strength of Tendon Repair and Migration of Bone Marrow Stromal Cells in Vitro.The Journal of bone and joint surgery. American volume · 2015Article
- Muscle-derived stem cell seeded fibrin gel interposition produces greater tendon strength and stiffness than collagen gel in vitro.The Journal of hand surgery, European volume · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo investigate the ability of muscle-derived stem cells (MDSCs) supplemented with growth and differentiation factor-5 (GDF-5) to improve tendon healing compared with bone marrow stromal cells (BMSCs) in an in vitro tendon culture model.
methodsEighty canine flexor digitorum profundus tendons were assigned into 5 groups: repaired tendon (1) without gel patch interposition (no cell group), (2) with BMSC-seeded gel patch interposition (BMSC group), (3) with MDSC-seeded gel patch interposition (MDSC group), (4) with GDF-5-treated BMSC-seeded gel patch interposition (BMSC+GDF-5 group), and (5) with GDF-5-treated MDSC-seeded gel patch interposition (MDSC+GDF-5 group). After culturing for 2 or 4 weeks, the failure strength of the healing tendons was measured. The tendons were also evaluated histologically.
resultsThe failure strength of the repaired tendon in the MDSC+GDF-5 group was significantly higher than that of the non-cell and BMSC groups. The stiffness of the repaired tendons in the MDSC+GDF-5 group was significantly higher than that of the non-cell group. Histologically, the implanted cells became incorporated into the original tendon in all 4 cell-seeded groups.
conclusionsInterposition of a multilayered GDF-5 and MDSC-seeded collagen gel patch at the repair site enhanced tendon healing compared with a similar patch using BMSC. However, this increase in vitro was relatively small. In the clinical setting, differences between MDSC and BMSC may not be substantially different, and it remains to be shown that such methods might enhance the results of an uncomplicated tendon repair clinically. CLINICAL RELEVANCE: Muscle-derived stem cell implantation and administration of GDF-5 may improve the outcome of tendon repair.
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