ArticleNature genetics2014
Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 378 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
378 citing papers in PubMed, 2 syntheses or guidelines pooled it, 747 citations in OpenAlex.
- Machine learning for multi-omics data integration in crop improvement: a systematic review.BMC bioinformatics · 2026Pooled it
- Exploring and exploiting genetics and genomics for sweetpotato improvement: Status and perspectives.Plant communications · 2022Pooled it
- Integration of the D-Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative Genome-Wide Association Studies of Metabolites and Grain-Related Traits in Common Wheat.Plant biotechnology journal · 2026Article
- Integrated Transcriptomic and Metabolomic Mining of Candidate Genes for Weevil Resistance in Pea.Plants (Basel, Switzerland) · 2026Article
- Research progress on flavonoid-mediated communication between plants and rhizosphere microorganisms.Archives of microbiology · 2026Review
- Genetic Architecture of Grain Protein Content in Hulless Barley: Insights from Multi-Environment GWAS.Plants (Basel, Switzerland) · 2026Article
- Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.Nature genetics · 2026Article
- Population genomic analysis and genome-wide association mapping of leaf morphology in Phyllanthus emblica L.BMC plant biology · 2026Article
- Roles of Metabolites Unveiled by Metabolomics inMetabolites · 2026Review
- Genetic characteristics and agronomic traits in leafy head Chinese cabbage breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- BloomSight: An ultra-high-frequency phenotyping framework for diurnal flowering dynamics inPlant phenomics (Washington, D.C.) · 2026Article
- Genome-wide association analysis and molecular marker development for effective tiller number in rice natural population.BMC plant biology · 2026Article
- Mining QTLs and candidate genes in bread wheat associated with kernel hardness through GWAS.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide association studies unravel genomic regions and candidate genes associated with Aspergillus flavus resistance in peanut kernels.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genome-Wide Association Study of Yield-Related Traits and Photoperiod Response in Rice.Plants (Basel, Switzerland) · 2026Article
- Modulating TPP riboswitch activity simultaneously enhances crop yield, nutritional quality and stress tolerance.Nature communications · 2026Article
- [Spatial omics in pulmonary fibrosis: advancing mechanistic insights and therapeutic strategies].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Integrating Metabolomics and Proteomics to Reveal the Regulatory Network Governing the Natural Variation in Rice Seed Germination Rate.Plants (Basel, Switzerland) · 2026Article
318 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant metabolites are important to world food security in terms of maintaining sustainable yield and providing food with enriched phytonutrients. Here we report comprehensive profiling of 840 metabolites and a further metabolic genome-wide association study based on ∼6.4 million SNPs obtained from 529 diverse accessions of Oryza sativa. We identified hundreds of common variants influencing numerous secondary metabolites with large effects at high resolution. We observed substantial heterogeneity in the natural variation of metabolites and their underlying genetic architectures among different subspecies of rice. Data mining identified 36 candidate genes modulating levels of metabolites that are of potential physiological and nutritional importance. As a proof of concept, we functionally identified or annotated five candidate genes influencing metabolic traits. Our study provides insights into the genetic and biochemical bases of rice metabolome variation and can be used as a powerful complementary tool to classical phenotypic trait mapping for rice improvement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.