ArticleBMC genomics2014
Infection routes matter in population-specific responses of the red flour beetle to the entomopathogen Bacillus thuringiensis.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
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- Pathogen growth and virulence dynamics drive the host evolution against coinfections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Resources modulate developmental shifts but not infection tolerance upon coinfection in an insect system.bioRxiv : the preprint server for biology · 2024Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- Idiosyncratic effects of bacterial infection on female fecundity inCurrent research in insect science · 2024Article
- Infection risk by oral contamination does not induce immune priming in the mealworm beetle (Frontiers in immunology · 2024Article
- Odorant-Binding and Chemosensory Proteins inInternational journal of molecular sciences · 2023Article
- Immune Stimulation via Wounding Alters Chemical Profiles of Adult Tribolium castaneum.Journal of chemical ecology · 2023Article
- Balancing sensitivity, risk, and immunopathology in immune regulation.Current opinion in insect science · 2022Review
- Oral Immune Priming Treatment Alters Microbiome Composition in the Red Flour BeetleFrontiers in microbiology · 2022Article
- Serial passage in an insect host indicates genetic stability of the human probioticEvolution, medicine, and public health · 2022Article
- Response Mechanisms of Invertebrates toMicrobiology and molecular biology reviews : MMBR · 2021Review
- An Expanded Survey of the Moth PBP/GOBP Clade inFrontiers in physiology · 2021Article
- Exogenous Gene Expression and Insect Resistance in Dual Bt ToxinFrontiers in plant science · 2021Article
- Experimental evolution of immunological specificity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPathogens can infect their hosts through different routes. For studying the consequences for host resistance, we here used the entomopathogen Bacillus thuringiensis and the red flour beetle Tribolium castaneum for oral and systemic (i. e. pricking the cuticle) experimental infection. In order to characterize the molecular mechanisms underpinning the two different infection routes, the transcriptomes of beetles of two different T. castaneum populations--one recently collected population (Cro1) and a commonly used laboratory strain (SB)--were analyzed using a next generation RNA sequencing approach.
resultsThe genetically more diverse population Cro1 showed a significantly larger number of differentially expressed genes. While both populations exhibited similar reactions to pricking, their expression patterns in response to oral infection differed remarkably. In particular, the Cro1 population showed a strong response of cuticular proteins and developmental genes, which might indicate an adaptive developmental flexibility that was lost in the SB population presumably as a result of inbreeding. The immune response of SB was primarily based on antimicrobial peptides, while Cro1 relied on responses mediated by phenoloxidase and reactive oxygen species, which may explain the higher resistance of this strain against oral infection.
conclusionsOur data demonstrate that immunological and physiological processes underpinning the two different routes of infection are clearly distinct, and that host populations particularly differ in responses to oral infection. Furthermore, gene expression upon pricking infection entailed a strong signal of wounding, highlighting the importance of pricking controls in future infection studies.
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