Evidence map›Paper›PMID 24907464›Full record

ReviewNanomedicine : nanotechnology, biology, and medicine2014

Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.

Erica J Carbone, Tao Jiang, Clarke Nelson, Nicole Henry, Kevin W-H Lo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanomedicine : nanotechnology, biology, and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε-caprolactone) Scaffolds Enhances Tendon-to-Bone Integration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Recent Advances in Scaffolds for Guided Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. AnStem cells international · 2021
    Review
  16. Review
  17. Nanotechnology Scaffolds for Alveolar Bone Regeneration.Materials (Basel, Switzerland) · 2020
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erica J CarboneInstitute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Tao JiangInstitute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Clarke NelsonInstitute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Nicole HenryInstitute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030.
Kevin W-H LoInstitute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, Connecticut 06268. Electronic address: wlo@uchc.edu.

Funding

Engineered Regeneration of Bone through a Small Molecule Cyclic Adenosine MonophoR21AR060480 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2011 to 2012
$450k
NIAMS NIH HHS NIH-R21-AR060480NIAMS NIH HHS R21 AR060480
6 · The paper itself

Abstract

Musculoskeletal regenerative engineering approach using small bioactive molecules in conjunction with advanced materials has emerged as a highly promising strategy for musculoskeletal repair and regeneration. Advanced biomaterials technologies have revealed nanofiber-based scaffolds for musculoskeletal tissue engineering as vehicles for the controlled delivery of small molecule drugs. This review article highlights recent advances in nanofiber-based delivery of small molecules for musculoskeletal regenerative engineering. The article concludes with perspectives on the challenges and future directions. FROM THE CLINICAL EDITOR: In this review, advances in nanofiber-based delivery of small molecules are discussed from the standpoint of their potential role in musculoskeletal regenerative engineering, highlighting both future directions and current challenges.

Indexed as

Musculoskeletal SystemBiocompatible MaterialsNanofibersNanotechnologyRegenerative MedicineTissue EngineeringTissue ScaffoldsBiocompatible MaterialsDrug deliveryMusculoskeletal disordersNanofibersSmall moleculesTissue engineering

Identifiers

PMID24907464
PMCPMC4497775

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.