ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Proliferation conditions promote intrinsic changes in NK cells for an IL-10 response.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Regulating the regulators via targeting CD38 in the tumor microenvironment.Frontiers in immunology · 2026Review
- Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals.Frontiers in immunology · 2022Article
- The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors.Exploration of targeted anti-tumor therapy · 2022Review
- IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance.Frontiers in immunology · 2021Review
- IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung.Translational research : the journal of laboratory and clinical medicine · 2020Article
- NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype.Oncoimmunology · 2020Article
- Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.Immunity · 2020Article
- IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18.Cancer immunology, immunotherapy : CII · 2020Article
- Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell.African health sciences · 2020Article
- Can Natural Killer Cells Be a Principal Player in Anti-SARS-CoV-2 Immunity?Frontiers in immunology · 2020Article
- Contributions of natural killer cells to the immune response against Plasmodium.Malaria journal · 2019Review
- Natural Killer Cell-Derived IL-10 Prevents Liver Damage During Sustained Murine Cytomegalovirus Infection.Frontiers in immunology · 2019Article
- The Role of IL-10 in Malaria: A Double Edged Sword.Frontiers in immunology · 2019Review
- NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.Frontiers in immunology · 2019Article
- Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.Immunity · 2018Article
- NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD.European journal of immunology · 2018Article
- EBI3 regulates the NK cell response to mouse cytomegalovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- NK Cells: Uncertain Allies against Malaria.Frontiers in immunology · 2017Review
- Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection.PLoS pathogens · 2016Article
- Regulatory Functions of Natural Killer Cells in Multiple Sclerosis.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Constitutively found at high frequencies, the role for NK cell proliferation remains unclear. In this study, a shift in NK cell function from predominantly producing IFN-γ, a cytokine with proinflammatory and antimicrobial functions, to producing the immunoregulatory cytokine IL-10 was defined during extended murine CMV infection. The response occurred at times subsequent to IL-12 production, but the NK cells elicited acquired responsiveness to IL-12 and IL-21 for IL-10 production. Because neither IL-12 nor IL-21 was required in vivo, however, additional pathways appeared to be available to promote NK cell IL-10 expression. In vitro studies with IL-2 to support proliferation and in vivo adoptive transfers into murine CMV-infected mice demonstrated that NK cell proliferation and further division enhanced the change. In contrast to the sustained open profile of the IFN-γ gene, NK cells responding to infection acquired histone modifications in the IL-10 gene indicative of changing from a closed to an open state. The IL-10 response to IL-12 was proliferation dependent ex vivo if the NK cells had not yet expanded in vivo but independent if they had. Thus, a novel role for proliferation in supporting changing innate cell function is reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.