ArticleGenetics2014
How population growth affects linkage disequilibrium.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Demography and Localized Reservoirs of Diversity Underlie Global Divergence in the Giant Kelp Macrocystis pyrifera.Molecular ecology · 2026Article
- Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Diversification in ANME-1 archaea is associated with the presence of highly variable genomic hotspots.Nature communications · 2026Article
- Inferring hominin history with recurrent gene flow from single unphased genomes and a two-locus statistic.bioRxiv : the preprint server for biology · 2026Article
- Pollution-Driven Selection in a Non-Biting Midge: Genome-Wide Responses to Bacillus thuringiensis israelensis and Copper.Molecular ecology · 2026Article
- Population History Across Timescales in an Urban Archipelago.Genome biology and evolution · 2025Article
- Population history across timescales in an urban archipelago.bioRxiv : the preprint server for biology · 2025Article
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- Phenotypic and ancestry-related assortative mating in autism.Molecular autism · 2024Article
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- Linkage Disequilibrium, Haplotype Block Structures, Effective Population Size and Genome-Wide Signatures of Selection of Two Conservation Herds of the South African Nguni Cattle.Animals : an open access journal from MDPI · 2022Article
- Linkage disequilibrium between rare mutations.Genetics · 2022Article
- Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages.Nature communications · 2022Article
- Assessing accuracy of genotype imputation in the Afrikaner and Brahman cattle breeds of South Africa.Tropical animal health and production · 2022Article
- Article
- Genetic diversity and population structure of six South African Acacia mearnsii breeding populations based on SSR markers.Journal of plant research · 2021Article
- Adaptive Divergence of Meiotic Recombination Rate in Ecological Speciation.Genome biology and evolution · 2020Article
- Estimation of Linkage Disequilibrium and Effective Population Size in Three Italian Autochthonous Beef Breeds.Animals : an open access journal from MDPI · 2020Article
- Predicting the Landscape of Recombination Using Deep Learning.Molecular biology and evolution · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "LD curve" relates the linkage disequilibrium (LD) between pairs of nucleotide sites to the distance that separates them along the chromosome. The shape of this curve reflects natural selection, admixture between populations, and the history of population size. This article derives new results about the last of these effects. When a population expands in size, the LD curve grows steeper, and this effect is especially pronounced following a bottleneck in population size. When a population shrinks, the LD curve rises but remains relatively flat. As LD converges toward a new equilibrium, its time path may not be monotonic. Following an episode of growth, for example, it declines to a low value before rising toward the new equilibrium. These changes happen at different rates for different LD statistics. They are especially slow for estimates of [Formula: see text], which therefore allow inferences about ancient population history. For the human population of Europe, these results suggest a history of population growth.
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