ArticleArchives of disease in childhood. Fetal and neonatal edition2014
Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Hypercalcemia of Down Syndrome.JCEM case reports · 2025Article
- A Hypercalcemic Crisis Complicating Subcutaneous Fat Necrosis of the Newborn: A Case Report and Literature Review.Cureus · 2024Article
- Case Report: Hypercalcemia, subcutaneous fat necrosis and nephrocalcinosis in neonates who undergo therapeutic hypothermia: a not so rare association, with different onset time.Frontiers in pediatrics · 2024Article
- Article
- Foetal Intrapartum Compromise at Term: Could COVID-19 Infection Be Involved? A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- The cause of severe hypercalcaemia resistant to pamidronate treatment: subcutaneous fat necrosis with no visible skin lesion.Sudanese journal of paediatrics · 2022Article
- Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association.BMJ case reports · 2021Article
- Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature.Children (Basel, Switzerland) · 2021Article
- Subcutaneous fat necrosis of the newborn - An atypical case with typical complications.Clinical case reports · 2021Article
- Pamidronate as first-line treatment of hypercalcemia in neonatal subcutaneous fat necrosis: A case series.Paediatrics & child health · 2021Article
- Calcium management challenges in a macrosomic child with subcutaneous fat necrosis.BMJ case reports · 2019Article
- An irritable newborn with tender red bumps.Paediatrics & child health · 2017Article
- Subcutaneous fat necrosis in neonates after therapeutic hypothermia - report of two cases.Postepy dermatologii i alergologii · 2016Article
- Subcutaneous fat necrosis of the newborn.Clinical case reports · 2015Article
- Subcutaneous Fat Necrosis of the Newborn: A Case Report of a Term Infant Presenting with Malaise and Fever at Age of 9 Weeks.Case reports in pediatrics · 2015Article
- PTHrP-related Hypercalcaemia in Infancy and Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).Canadian journal of kidney health and disease · 2015Article
- Brown fat necrosis with calcifications in the newborn: Risk factors, radiographic findings, and clinical course.The Indian journal of radiology & imagingArticle
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4 authors.
Funding
Abstract
objectiveSubcutaneous fat necrosis (SCFN) is a rare form of panniculitis in infants that generally occurs following birth trauma, meconium aspiration, or therapeutic cooling. Severe hypercalcaemia occurs in a subset of patients, but data on its presentation, management and outcomes are limited. This report details the clinical course and complications of infants treated for severe hypercalcaemia (peak serum calcium ≥3.0 mmol/L) due to SCFN.
designChart review of all infants with SCFN seen at a single paediatric centre over a 13-year period. PATIENTS: Seven infants with SCFN developed severe hypercalcaemia, with median peak serum calcium 4.1 mmol/L (range 3.3-5.1).
resultsSevere hypercalcaemia occurred before 6 weeks of age, and was asymptomatic in 3/7 patients (43%). Most patients were treated with intravenous hydration, furosemide, glucocorticoids and low-calcium formula, which restored normocalcaemia in a median of 9 days (range 2-42). Fever developed during treatment in 4/7 infants (57%): two patients had bacterial infections and two had no infectious source identified. Nephrocalcinosis was present in 5/6 patients (83%) who were evaluated by renal ultrasound. Nephrocalcinosis failed to resolve in all cases over a median follow-up of 20 months (range 8-48), but no renal dysfunction was observed. Eosinophilia, which has not been reported previously in SCFN, was present in 6/7 patients (86%).
conclusionsIn this largest series to date of infants with severe hypercalcaemia due to SCFN, novel findings include the common occurrence of fever and a high incidence of persistent nephrocalcinosis without evidence of adverse renal outcomes.
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