ArticleJournal of endocrinological investigation2014
Relationship between glucose metabolism and non-alcoholic fatty liver disease severity in morbidly obese women.
Article in Journal of endocrinological investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Machine Learning-Based Routine Laboratory Tests Predict One-Year Cognitive and Functional Decline in a Population Aged 75+ Years.Brain sciences · 2023Article
- Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome.Clinical epigenetics · 2019Review
- Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.JAMA network open · 2019Article
- The Liver in Children With Metabolic Syndrome.Frontiers in endocrinology · 2019Review
- Twenty-five-year trajectories of insulin resistance and pancreatic β-cell response and diabetes risk in nonalcoholic fatty liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2018Article
- NAFLD/NASH in patients with type 2 diabetes and related treatment options.Journal of endocrinological investigation · 2018Review
- Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males.Scientific reports · 2017Article
- Does segmental body composition differ in women with Prader-Willi syndrome compared to women with essential obesity?Journal of endocrinological investigation · 2015Article
- Hepatic Steatosis as a Marker of Metabolic Dysfunction.Nutrients · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-alcoholic fatty liver disease (NAFLD) is an independent predictor of type 2 diabetes mellitus (T2DM). Insulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM. Insulin resistance is associated with NAFLD but little is known about beta-cell dysfunction and NAFLD.
aimWe tested whether NAFLD severity is associated with insulin sensitivity and beta-cell function in morbidly obese women. SUBJECTS AND
methodsWe studied 61 Caucasian women aged 18-60 years without T2DM and with a body mass index ranging from 35.3 to 48.8 kg/m². The insulin sensitivity index (ISI) and the disposition index (DI) from oral glucose tolerance testing were used as measures of insulin sensitivity and beta-cell function, respectively. Fat was measured by dual-energy X-ray absorptiometry. Fatty liver was diagnosed by ultrasonography and ordinally coded as 0 = none, 1 = light, 2 = moderate, 3 = severe. Proportional-odds logistic regression was used to evaluate the association of NAFLD severity with log(e)ISI and log(e)DI with and without correction for total and truncal fat.
resultsThe odds of more severe vs. less severe NAFLD decreased for increasing log(e)ISI [odds ratio (OR) 0.40, 95 % CI 0.19-0.84, p < 0.05] and log(e)DI (OR 0.80, 95 % CI 0.69-0.92, p < 0.01). Neither total nor truncal fat had any effect on these associations.
conclusionIn morbidly obese women, NAFLD severity is inversely associated with insulin sensitivity and beta-cell function. The association of NAFLD severity with beta-cell dysfunction is stronger than that with insulin resistance.
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