ArticleThe Lancet. Infectious diseases2014
Research into a functional cure for HIV in neonates: the need for ethical foresight.
Article in The Lancet. Infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure.Frontiers in immunology · 2022Review
- Ethics of HIV cure research: an unfinished agenda.BMC medical ethics · 2021Review
- Lessons Learned From Failures and Success Stories of HIV Breakthroughs: Are We Getting Closer to an HIV Cure?Frontiers in microbiology · 2020Review
- When to start paediatric testing of the adult HIV cure research agenda?Journal of medical ethics · 2017Article
- Inequality and ethics in paediatric HIV remission research: From Mississippi to South Africa and back.Global public health · 2017Article
- How to keep high-risk studies ethical: classifying candidate solutions.Journal of medical ethics · 2017Article
- HIV cure research in South Africa: a preliminary exploration of stakeholder perspectives.AIDS care · 2016Article
- Ethics of HIV research in children.The Lancet. Infectious diseases · 2015Article
- Research gaps in neonatal HIV-related care.Southern African journal of HIV medicine · 2015Article
- The ethics of HIV "cure" research: what can we learn from consent forms?AIDS research and human retroviruses · 2015Article
- Very early combination antiretroviral therapy in infants: prospects for cure.Current opinion in HIV and AIDS · 2015Review
- What motivates participation in HIV cure trials? A call for real-time assessment to improve informed consent.Journal of virus eradication · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
In 2013, researchers announced that a newborn child from Mississippi, USA might have been functionally cured of HIV by being given combination antiretroviral therapy within hours of birth. Public and media attention has since been captured by the possibility of finding a cure for HIV transmitted from mother to child. Research into the strategy used for the Mississippi patient is crucially important to establish whether it can be replicated and shown to work in diverse populations. At the same time, any ethical issues likely to arise in such studies should be addressed and not ignored in the pursuit of a functional cure. In this Personal View we identify ethical issues that could arise in research towards achievment of a functional cure for HIV in neonates, including difficult trade-offs associated with choosing the study population and questions about the broader social implications of the research, and propose ways to resolve them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.